原发性高血压患者动脉弹性与窦性心率震荡现象的相关性

Relationship of artery elasticity function and heart rate turbulence in patients with essential hypertension

目的观察和分析原发性高血压(essential hypertesion,EH)患者中动脉弹性功能与窦性心率震荡(heart rate turbulence,HRT)现象有无相关性。方法连续入选EH患者150例,测定每位患者的颈-股动脉脉搏波传导速度(carotid-femoral pulse wave velocity,CF-PWV),根据CF-PWV将患者分为3组:A组45例(CF-PWV≤10 m/s),B组49例(10 m/s<CF-PWV<12 m/s),C组56例(CF-PWV≥12 m/s)。同时对每位入选患者分别进行24动态心电监测,分别计算出HRT的评价指标震荡初始、震荡斜率并进行组间比较。结果多因素分析发现年龄、吸烟、震荡初始和震荡斜率是动脉弹性功能的独立相关因素(均P<0.01),其中吸烟和震荡斜率与动脉弹性功能呈负相关。对动脉弹性与震荡初始、震荡斜率采用Pearson相关性分析,发现动脉弹性与震荡初始呈正相关(r=0.583,P<0.01),与震荡斜率呈负相关(r=-0.574,P<0.01)。结论在EH患者中,动脉弹性功能与HRT密切相关。

AIM To observation and analysis whether there is a relationship between artery elasticity and heart rate turbulence in patients with essential hypertension. METHODS 150 continuously selected patients with essential hypertension were enrolled into the study. Artery elasticity function was evaluated by detecting the carotid-femoral pulse wave velocity（CF-PWV）. Each patient was performed for 24 hours holter monitoring. The indexes of heart rate turbulence were calculated and compared between groups, including turbulence onset and turbulence slope. Patients were divided into four groups by age（21-30, 31-40, 41-50, 51-60 years old） and artery elasticity was compared between groups meanwhile. RESULTS Age, smoking, turbulence onset and turbulence slope was closely related to artery elasticity function （all P〈0.01）. Pearson correlation analysis was used to evaluate artery elasticity function, turbulence onset and turbulence slope , results showed a positive correlation （related coefficient=0.583, P〈0.01） between artery elasticity and turbulence onset, while artery elasticity and turbulence slope was negative correlated（related coefficient=-0.574, P〈0.01）. CONCLUSION Artery elasticity function is closely related to heart rate turbulence in patients with essential hypertension.