摘要
The title compound 14-O-[（2-chloroacetamide-6-aminopyrimidine-2-yl） thioacetyl] mutilin（4）, C（28）H（39）ClN4O5S, was prepared and characterized by IR, NMR, HRMS and singlecrystal X-ray diffraction. The title compound crystallizes in orthorhombic system, space group P212121 with a = 11.5388（8）, b = 14.5282（10）, c = 19.8301（14） A, V = 3324.3（4）A3, Z = 4, Dc = 1.396 g/cm3, μ（Mo Kα） = 0.462 mm-1, F（000） = 1464, S = 1.003, R = 0.0386 and wR = 0.1014 for 5170 independent reflections（Rint = 0.0224） with I 〉 2σ（I））. The preliminary in vitro antibacterial bioassay against methicillin-resistant Staphylococcus aureus（MRSA-ATCC25923）, Staphylococcus aureus（S. aureus）, Escherichia coli（E. coli）, and Staphylococcus warneri（S.warneri） were screened and the MIC values of the title compound were 0.125, 0.0625, 8 and 0.5 μg/m L, respectively.
The title compound 14-O-[（2-chloroacetamide-6-aminopyrimidine-2-yl） thioacetyl] mutilin（4）, C（28）H（39）ClN4O5S, was prepared and characterized by IR, NMR, HRMS and singlecrystal X-ray diffraction. The title compound crystallizes in orthorhombic system, space group P212121 with a = 11.5388（8）, b = 14.5282（10）, c = 19.8301（14） A, V = 3324.3（4）A3, Z = 4, Dc = 1.396 g/cm3, μ（Mo Kα） = 0.462 mm-1, F（000） = 1464, S = 1.003, R = 0.0386 and wR = 0.1014 for 5170 independent reflections（Rint = 0.0224） with I 〉 2σ（I））. The preliminary in vitro antibacterial bioassay against methicillin-resistant Staphylococcus aureus（MRSA-ATCC25923）, Staphylococcus aureus（S. aureus）, Escherichia coli（E. coli）, and Staphylococcus warneri（S.warneri） were screened and the MIC values of the title compound were 0.125, 0.0625, 8 and 0.5 μg/m L, respectively.
基金
Supported by Lanzhou Science and Technology Development Project(No.2016-3-101)
