摘要
The title compound（2S,3S,E）-4-（3,4-dihydroxybenzylidene）-3-（3,4-dihydroxyphenyl）-5-oxotetrahydrofuran-2-carboxylic acid was synthesized and the 2D structure was characterized by ^1H-NMR ^13C-NMR and LCMS. The absolute configuration was determined by single-crystal X-ray diffraction of the key intermediate（2S,3S,E）-ethyl 4-（3,4-dimethoxybenzylidene）-3-（3,4-dimethoxyphenyl）-5-oxotetrahydrofuran-2-carboxylate. The crystal belongs to tetragonal system, space group P41 with a = 13.0665（2）, b = 13.0665（2）, c = 13.4735（2）A, V = 2300.4（6） A^3, Z = 4, Dc = 1.278 g/cm^3, μ（CuKα） = 0.801 mm^-1, F（000） = 936, S = 1.050, R = 0.0364 and wR（I 〉 2σ（I）） = 0.1071. X-ray diffraction results showed that the molecular structure is stabilized totally by Van der Waals force. The antibacterial activity tests showed that the title compound possesses slight synergistic effect against MRSA and Acinetobacter baumanii.
The title compound（2S,3S,E）-4-（3,4-dihydroxybenzylidene）-3-（3,4-dihydroxyphenyl）-5-oxotetrahydrofuran-2-carboxylic acid was synthesized and the 2D structure was characterized by ^1H-NMR ^13C-NMR and LCMS. The absolute configuration was determined by single-crystal X-ray diffraction of the key intermediate（2S,3S,E）-ethyl 4-（3,4-dimethoxybenzylidene）-3-（3,4-dimethoxyphenyl）-5-oxotetrahydrofuran-2-carboxylate. The crystal belongs to tetragonal system, space group P41 with a = 13.0665（2）, b = 13.0665（2）, c = 13.4735（2）A, V = 2300.4（6） A^3, Z = 4, Dc = 1.278 g/cm^3, μ（CuKα） = 0.801 mm^-1, F（000） = 936, S = 1.050, R = 0.0364 and wR（I 〉 2σ（I）） = 0.1071. X-ray diffraction results showed that the molecular structure is stabilized totally by Van der Waals force. The antibacterial activity tests showed that the title compound possesses slight synergistic effect against MRSA and Acinetobacter baumanii.
基金
financially sponsored by the Shanghai Rising-Star Program(B)(16QB1403800)
