动脉斑块新生血管的研究进展

Progress of carotid plaque neovascularization

斑块内新生血管对斑块稳定性的影响是临床研究的热点,尤其是颈动脉斑块、冠状动脉斑块内的新生血管与心血管终点事件发生的相关性,越来越受到临床医生的关注。本文通过对斑块内新生血管发生、发展机制的阐述,讨论斑块内不成熟的新生血管是否存在某种机制,可以使其转化为成熟的新生血管;探讨颈动脉斑块内新生血管的成熟度引起缺血性脑卒中某种新的发病机制,为今后的研究奠定一定的基础。

Plaque neovascularization impacted on the stability of the plaques is becoming a hot spot in clinical research, especially the relationship between the angiogenesis in carotid artery plaque, coronary artery plaque and the cardiovascular events has aroused more and more concerns of doctors. Based on the plaque angiogenesis and development mechanism in this paper, whether there is some kind of mechanism could make the premature newborn blood vessels differentiated into maturation is discussed. And exploration is made in the new mechanism in which the maturity of plaque neovascularization caused a stroke. All of them will establish stability theoretical foundation for continue study work.