IL-12家族与自身免疫性甲状腺疾病

IL-12 family and autoimmune thyroid disease

IL-12细胞因子家族成员包括IL-12,IL-23,IL-27和IL-35。上述家族成员具有相似的异质二聚体亚基结构,但它们的生物学功能截然不同,IL-12和IL-23是Th1、Th17促炎反应的增强剂,IL-27具有促炎和抑炎双向调节作用,而IL-35是重要的抑炎细胞因子。IL-12家族是近年来炎症和免疫学研究中一个较新且重要的标志,作为调节因子和标志物,它们与多种自身免疫性疾病的发生和发展密切相关。但IL-12家族与自身免疫性甲状腺疾病(AITD)关系的研究至今报道较少,本文拟就这方面的进展作一综述。

The IL-12 family members are consisted of IL-12,IL-23,IL-27,and IL-35. The above family members have similar heterodimeric structures,but their biological characteristics are very diverse,IL-12 and IL-23 are pro-inflammatory activators of Th1 and Th17 responses,IL-27 is bidirectional for inflammation,while IL-35 is a vital inhibitory cytokine. IL-12 family is an important inflammatory and immunological playmaker in recent years,as regulators and playmakers,they are closely associated with the occurrence and the development of many autoimmune diseases. But studies on the relationship between IL-12 family and autoimmune thyroid disease（ AITD） reported so far are not many,this article summarizes the progresses on this topic.