盘状结构域受体酪氨酸激酶1与炎症关系的研究进展

Advances in the Study of the Relationship between Discoidin Domain Receptor Tyrosine Kinases 1 and Inflammation

盘状结构域受体酪氨酸激酶1(DDR1)是新发现的一种受体酪氨酸激酶,可以与其配体——胶原蛋白特异性结合,而这种结合可导致位于胞内区的酪氨酸激酶缓慢而持续的磷酸化,这种磷酸化可参与细胞的增殖、分化、黏附、迁移以及炎症信号通路的活化,进而导致多种病理学的改变,如纤维化和恶性肿瘤的发生、发展。同时,DDR1还可参与多个脏器的炎症反应,如肝炎、肾炎、中枢神经系统炎症等。未来,需进一步研究DDR1是否参与其他脏器的炎症反应,力求全面反映DDR1在炎症中所发挥的作用。

Discoidin domain receptor tyrosine kinases 1 （ DDR1 ） is a newly discovered type of receptor tyrosine kinase, and can specially bind a number of different native collagen types. This binding leads to slow and continuous phosphorylation of tyrosine kinases located in the intraeeilular part of the receptor, involved in cell proliferation, differentiation, adhesion, migration and activation of the inflammation signal pathway, which are involved in a variety of pathological changes such as fibrosisand the occurrence and development of malignant tumors. In addition, DDR1 is ＇also involved in inflammatory reac- tions of multiple organs, such as hepatitis, nephritis, central nervous system inflammation, etc. In the future, further study on whether DDR1 is involved in the inflammatory response of other organs still needed, so as to fully reflect the role of DDR1 in inflammation.