系统性红斑狼疮合并肺动脉高压的早期预测指标研究进展

Research Progress of Early Predictors of Systemic Lupus Erythematosus Combined with Pulmonary Arterial Hypertension

系统性红斑狼疮(SLE)是一种多器官受累的好发于年轻女性的自身免疫性疾病,其所造成的器官损害及功能衰竭是导致SLE患者预后不良的重要原因之一。肺动脉高压(PAH)是一种病理生理综合征,病因复杂多样。多种结缔组织病可合并PAH,但在中国以SLE患者最常见。SLE合并PAH患者临床表现隐匿,治疗效果欠佳,预后不良。研究SLE合并PAH的早期预测指标能使患者及早的诊断和治疗,从而提高生活质量及存活率。关于SLE合并PAH的早期预测指标,国内外学者均有报道,但研究结果并不一致,甚至互相矛盾。因此,未来需要更权威的大样本研究探讨SLE合并PAH的早期预测指标,以助于临床医师早期诊断PAH。

Systemic lupus erythematosus （ SLE ） is a multi-organ autoimmune disease, which occurs mostly in young women. Organ damage and failure caused by SLE is one of the important causes of SLE patients with poor prognosis. Pulmo- nary arterial hypertension（PAH） is a pathophysiology syndrome and the etiology is complicated. A variety of connective tis- sue diseases can merge pulmonary hypertension,but the most common in China are SLE patients. The clinical manifestation is not obvious, therapeutic effects is unsatisfactory and the prognosis is poor in SLE patients with PAH. Early diagnosis and treatment of SEE patients combined PAH can improve the patients＇ quality of life and survival. Domestic and foreign schol- ars have all reported the early predictors of SLE combined with PAH, but the research results are inconsistent and even con- tradictory. Therefore, a more authoritative large-sample study is needed to explore early predictors of SLE with PAH to assist the clinicians in early diagnosis of PAH.