肠道菌群对缺血性脑卒中影响的研究进展

Research Progress of the Influence of Gut Microbiota on Ischemic Stroke

目前,肠道菌群在神经系统疾病中的作用已得到广泛研究,但仅有少部分研究强调了肠道菌群在脑卒中发病机制中的重要性,且具体影响机制尚不明确。肠道菌群不仅影响机体的吸收、代谢功能,还对血压、血糖、血脂和动脉粥样斑块形成有重要作用,这些均为脑卒中发病的危险因素。同时,肠道菌群的改变会影响宿主的免疫平衡,产生的炎性因子,一部分加重了缺血性脑损伤,另一部分却发挥神经保护作用。未来,进一步研究肠道菌群在缺血性脑卒中中的确切机制和作用,将为缺血性脑卒中的治疗及预防提供新方向。

Currently, the role of gut microbiota in nervous system disease has been widely studied, but only few studies emphasize the importance of gut microflora in the pathogenesis of stroke, and the specific impact mechanism is unclear. Gut microbiota not only affects the absorption and metabolism of the body, but also plays an important role in the blood pressure, blood glucose, blood lipid and the formation of atherosclerotic plaques, which are all risk factors for stroke. Meanwhile, the change of gut microbiota may affect the host＇s immune balance,producing the inflammatory factors, some of which aggravate ischemic brain injury,while the others have neuroprotective effect. In the future, further study of the exact mechanism and role of gut microbiota in ischemic stroke will provide new directions for the treatment and prevention of ischemic stroke.