犬黄体功能调控机制研究进展

Research Progress on Regulatory Mechanisms of Canine Corpus Luteum Function

犬黄体具有异于其他家畜的生理结构和功能表现,其中最特别的是犬缺乏急性黄体溶解机制。犬黄体发生过程受催乳素、促黄体素和前列腺素E2的复杂调控,溶解退化过程则对其他家畜主要的溶黄体激素——前列腺素F2α不敏感。而黄体的存留对母犬的生殖活动却具有重要的意义,其自分泌或旁分泌的类固醇激素也在妊娠调控和发情周期的更迭中发挥重要作用。犬黄体的退化机制尚未明确,但国外已有包括被动退化在内的诸多假说。此外,黄体是为数不多具有完整生命周期的功能性组织(或器官),其发生过程、功能实现和衰老溶解都在周而复始地进行,这对炎症反应、癌症发生和细胞凋亡等研究都具有重要的参考价值。作者综述了犬黄体的发生和退化过程中调控机制的研究进展,旨在为进一步深入研究犬黄体发生和退化的分子机制提供研究背景和理论依据。

Significant differences can be found in the physiology construction and functional performance of canine corpus luteum from the other domestic animal species,and the most interesting characteristic is the lack of an acute luteolytic mechanism.It is a multifactorial process that luteinization of canine is regulated by PRL,LH and PGE2,and the luteolysis is insensitive to PGF2α.The remaining canine corpus luteum plays an important role in bitch reproductive activities,and the steroid hormone from it through autocrine or paracrine is the same important to pregnancy and the estrus cycle.It is still unknown about the mechanism of regression of canine corpus luteum,however,there are several hypotheses including the passive regression mechanism.Moreover,corpus luteum is one of the few tissues（organs）which includes all three parts formation,maintenance and regression of the life cycle,and it is very important for the research of inflammatory reaction,carcinogenesis and apoptosis.In this review,the advanced progress of formation and regression of canine corpus luteum were summarized,which would provide theoretical basis and research background to study the molecular mechanism in this filed.