摘要
目的研究人附睾蛋白4(human epididymis protein 4,HE4),神经元特异性烯醇化酶(2-phospho-D-glycerate hydrolase,N SE),细胞角蛋白19片段(cytokeratins19,CYFR A21-1)联合检测对肺癌的诊断价值。方法检测大连市中心医院67例肺癌患者,70例健康体检者,65例肺良性疾病患者血清中HE4,NSE,CYFRA21-1水平,分析各指标对肺癌的诊断价值。结果肺癌患者血清中HE4,NSE,CYFRA21-1水平显著高于肺良性疾病与健康对照组(P<0.05),与单次检查比较,联合检查可以提高检测的灵敏度。结论 HE4可以作为新的肺癌肿瘤标志物。联合检测血清中HE4,NSE,CYFRA21-1水平可以提高检测的灵敏度,提高肺癌的诊断价值。
Objective To explore the clinical significance of combined detection of serum HE4, NSE, CYERA21-I in patients with lung cancer.Methods The level of serum HE4,NSE,CYFRA21-1 of 67 patients with lung cancer from Dalian Central Hospital, 70 cases of healthy people and 65 patients with pulmonary diseases were measured and analyzed for their value in the detection of lung cancer.Results The serum level of HE4 ,NSE, CYFRA21-1 in lung cancer group were significantly higher than those of the other two control groups （P〈0.05）.The sensitivity rate of joint detection of three tumor markers were significantly higher than those of single detection.Conclusion HE4 may be used as a new biomarker of lung cancer.The combined detection of serum HE4, NSE, CYFRA21-1 could increase the sensitivity of the patients with lung cancer and is of great value in lung cancer detection.
出处
《中国疗养医学》
2017年第10期1081-1083,共3页
Chinese Journal of Convalescent Medicine
