运动结合饮食控制通过降低RAAS系统活性改善男性肥胖青少年血管内皮功能

Exercise Combined with Diet Control Improving Male Obese Adolescents' Vascular Endothelial Function through Reducing the Activity of RAAS System

目的:通过检测封闭式运动减肥训练营中肥胖青少年血管内皮功能及RAAS系统主要成分的变化,揭示运动结合饮食控制改善肥胖青少年血管内皮功能的生物学机制。方法:32名男性单纯性肥胖青少年,年龄:15.38±2.82岁,BMI:33.21±4.23 kg/m^2。接受为期6周的运动结合饮食控制,采用Endo PAT-2000系统测试受试者实验前后的指端反应性充血指数(RHI),并对血清NO、内皮素(ET-1)、肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、血管紧张素原(AGT)、血管紧张素转换酶(ACE)、醛固酮(ALD)水平、身体形态、糖脂代谢、血压进行检测。结果:经过6周运动结合饮食控制干预,肥胖青少年身体成分、围度和糖脂代谢指标明显改善。RHI(P<0.01)和血清中NO/ET-1(P<0.01)显著上升,血清PRA、AngⅡ和ALD(P<0.05、P<0.01和P<0.01)显著下降。运动结合饮食控制干预前后血清PRA、AngⅡ和ALD的变化程度呈显著正相关,而AngⅡ与RHI变化程度呈显著负相关(r=-0.562,P=0.003)。结论:肥胖青少年RAAS系统活性显著提高。6周的运动结合饮食控制,能够有效改善肥胖青少年的血管内皮功能,其机制可能与运动结合饮食控制降低了RAAS系统活性有关。

Objective： To reveal biological mechanisms of exercise combined with diet control to improve obese adolescents＇ endothelial function by detecting the change of endothelial function and the RAAS system main components in enclosed exercise weight loss camp. Method： 32 male obese adolescents take a 6-weeks exercise combined with diet control intervention. The Reactive Hyperemia Index （RHI） was detected using EndoPAT-2000 system before and after intervention. Mean-while the serum levels of NO, ET-1, PRA, Ang Ⅱ, AGT, ACE, ALD, body morphology, glucolipid metabolism and BP were tested. There was a significant positive correlation between the changes of serum PRA, Ang II and ALD belong the intervention of diet and control, and a significant negative correlation between Ang Ⅱ and RHI （r=-0.562, P=0.003 ）. Result： After 6-weeks intervention, obese adolescents＇ body morphology, girth and glucolipid metabolism are significantly improved. RHI （P〈 0.01 ） and serum levels of NO/ET-1 （P〈 0.01 ） are significantly increased, while PRA, Ang II and ALD significantly decreased （P〈 0.05,P〈 0.01 and P〈 0.01 ）. A Ang Ⅱ and A RHI has significant negative correlation （r=-0.562, P=0.003）. Conclusion： The activity of RAAS system in obese adolescents is increased significantly. The 6-weeks exercise combined with diet control intervention can improve vascular endothelial function in obese adolescents effectively and its mechanisms may be related to the decreased activity of RAAS system after exercise combined with diet control.