益肾除颤汤联合多巴丝肼片治疗帕金森病随机对照研究

Effect of Yishen Chuchan Decoction Combined with Madopar on Parkinson's Disease: A Randomized Controlled Trial

目的观察益肾除颤汤联合多巴丝肼片治疗帕金森病的疗效。方法将86例帕金森病患者按随机数字表法分为治疗组和对照组,每组43例,治疗组予多巴丝肼片加益肾除颤汤口服治疗,对照组予多巴丝肼片加安慰剂口服治疗,连续治疗2个月。观察患者治疗前及治疗1、2个月帕金森病运动功能评定量表评分(MDRSPD)、统一帕金森病评定量表第三部分(UPDRSⅢ)评分、计时运动试验次数、非运动症状评价量表(NMSS)评分、帕金森病非运动症状问卷(NMSQuest)评分,观察两组患者服药后的安全性指标。结果与本组治疗前比较,两组患者治疗2个月后MDRSPD、UPDRSⅢ评分降低(P<0.05,P<0.01),左、右手计时运动试验次数均升高(P<0.05,P<0.01);治疗组治疗1、2个月NMSS和NMSQuest评分降低(P<0.05,P<0.01)。与对照组同期比较,治疗组治疗2个月UPDRSⅢ评分降低(P<0.05),左、右手计时运动试验次数升高(P<0.05),治疗1、2个月NMSS和NMSQuest评分降低(P<0.05,P<0.01)。结论益肾除颤汤联合多巴丝肼片可改善帕金森病症状。

Objective To observe the clinical efficacy of Yishen Chuchan Decoction combined with Madopar on Parkinson＇ s disease. Methods Totally 8 6 patients with Parkinson＇ s Disease（ PD） were randomized into two groups： the treatment group（ 4 3 cases） and the control group（ 4 3 cases）. During two consecutive months, patients in the treatment group received Madopar and Yishen Chuchan Decoction while patients in the control group were given Madopar and placebo orally. The motor dysfunction rating scale for Parkinson＇ s disease（ MDRSPD）,unified Parkinson＇ s disease rating scale Ⅲ（ UPDRS Ⅲ）,nonmotor symptom scale（ NMSS）,performance in chronograph movement（ times of left and right hand movement in one minute） and non-motor symptom questionnaire（ NMSQuest） were reviewed at three time points： before treatment,treatment for 1 month and treatment for 2 months. The safety parameters of the two groups were also observed after treatment. Results MDRSPD scores and UPDRS scores of both groups decreased after 2 months treatment compared with those before treatment（ P 0. 0 5,P 0. 0 1）. Meanwhile,the frequency of chronograph movement of left or right hand increased（ P 0. 0 5,P 0. 0 1）. In treatment group,NMSS scores and NMSQuest scores decreased after 1 and 2 months compared with those before treatment（ P 0. 0 5,P 0. 0 1）. Compared with control group,the UPDRS scores decreased and the frequency of chronograph movement increased in treatment group after 2 months（ P 0. 0 5）. The NMSS scores and NMSQuest scores decreased after 1 and 2 months in treatment group compared with con-trol group（ P 0. 0 5,P 0. 0 1）. Conclusion Yishen Chuchan Decoction combined with Madopar could improve the symptoms of Parkinson＇ s disease.