阿仑膦酸钠与钙尔奇D治疗绝经后骨质疏松疗效对比

Comparative Effect of Alendronate Sodium and Caltrate D in Treating Postmenopausal Osteoporosis

目的探讨阿仑膦酸钠与钙尔奇D治疗绝经后骨质疏松的疗效差异。方法选取医院2015年1月至2016年9月收治的绝经后骨质疏松患者80例,根据随机数字表法分为对照组(钙尔奇D组)和观察组(阿仑膦酸钠组),各40例,比较两组的临床疗效、症状改善时间及消失时间,以及治疗前后L1-4、股骨颈、大转子、全髋部的骨密度变化。结果与对照组相比,观察组治疗的总有效率明显增高(P<0.05),症状及体征改善时间及消失时间均明显缩短(P<0.05),治疗后L1-4、股骨颈、大转子、全髋部的骨密度均明显增加(P<0.05)。结论阿仑膦酸钠较钙尔奇D能更好地改善绝经后骨质疏松患者的骨密度,临床疗效更高。

Objective To investigate the different clinical efficacy of alendronate sodium and Caltrate D for treating postmenopausal osteoporosis. Methods Totally 80 patients with postmenopausal osteoporosis in our hospital from January 2015 to September 2016 were divided into the control group（ treatment of Caltrate D） and the observation group（ treatment of alendronate sodium） according to the random number method,40 patients in each group. The clinical efficacy,the symptoms improvement time and disappearance time,and the bone mineral density changes of L1-4, femoral neck, trochanter and total hip in two groups were compared before and after treatment. Results Compared with the control group,the total effective rate of the observation group was significantly increased（ P〈0. 05）.the symptoms improvement time and disappearance time of the observation group were obviously shorter（ P〈0. 05）,after treatment,the bone mineral density of L1-4, femoral neck, trochanter and total hip were significantly increased in the observation group（ P〈0. 05）.Conclusion Compared with Caltrate D,alendronate sodium can improve the bone mineral density in patients with postmenopausal osteoporosis,and increase clinical efficacy.