围绝经期妇女血脂水平与颈动脉硬化斑块相关性研究

Correlation Between Serum Lipid Level and Carotid Atherosclerosis Plaque in Perimenopausal Women

目的探讨围绝经期妇女血脂水平变化与颈动脉硬化斑块的相关性。方法随机选取在医院健康体检的围绝经期妇女186例,根据血脂检测结果分为血脂正常组(86例)和血脂异常组(100例)。采用彩超检测颈动脉内中膜厚度(IMT)及斑块发生情况,分析血脂变化与颈动脉斑块的关系。结果围绝经期妇女出现颈动脉内中膜增厚率为26.88%,合并内中膜增厚及粥样斑块形成率为36.56%。血脂异常组颈动脉内中膜增厚及粥样斑块的发生率,均高于血脂正常组。其中以高三酰甘油(TG)发生率最高,与其他表现相比,差异有统计学意义(P<0.05)。结论围绝经期妇女血脂水平变化与颈动脉硬化斑块存在重要关系,其中血脂异常的围绝经期妇女更易出现颈动脉粥样硬化及颈动脉内中膜增厚。

Objective To investigate the correlation between changes of serum lipid level and carotid atherosclerosis plaque in perimenopausal women. Methods Totally 186 perimenopausal women who came to our hospital for medical examination were randomly selected and divided into the ortholiposis group（ 86 cases） and the dyslipidemia group（ 100 cases） according to the examination results of serum lipid. The incidence of carotid intima-media thickness（ IMT） and plaque were detected by color Doppler ultrasonography,the relationship between changes of serum lipid level and carotid plaque was analyzed. Results The incidence rate of carotid intima-media thickness in perimenopausal women was 26. 88%,and the incidence rate of carotid intima-media thickness complicated with atherosclerotic plaque was 36. 56%,and the incidence rates of carotid intima-media thickness and atherosclerotic plaque in the dyslipidemia group were significantly higher than those in the ortholiposis group. The incidence rate of hypertriglyceridemia was the highest compared with the other symptoms,the difference was statistically significant（ P 〈 0. 05）. Conclusion There is an important relationship between between changes of serum lipid level and carotid atherosclerosis plaque in perimenopausal women,the perimenopausal women with dyslipidemia are more prone to carotid atherosclerosis and carotid intima-media thickness.