硒摄入与胰腺癌风险的Meta分析

Selenium Intake and Risk of Pancreatic Cancer: A Meta-analysis of Observational Studies

全球每年因胰腺癌死亡的人数超过25万。尽管有相关研究证实了胰腺癌的一些危险因素,但是饮食或营养素与胰腺癌的关系仍不明确。少数观察性研究探讨了硒摄入和胰腺癌的关系,但研究结果并不一致。将在Pub Med和Embase数据库中检索到的2017年5月前发表的相关观察性研究进行了meta分析,分析硒摄入和胰腺癌发病风险之间的关系,并利用随机效应模型计算总体效应量相对危险度(RR)及其95%可信区间(CI)。研究共纳入3项病例对照研究和3项队列研究,总的RR为0.76(95%CI:0.62~0.93),无异质性(P=0.66,I2=0%)和发表偏倚(Begg检验:P>0.1;Egger检验:P>0.1)。结果显示硒摄入可能降低胰腺癌的发病风险。

Globally, pancreatic cancer causes more than a quarter of a million deaths annually. Although some risk factors have been identified, the association between diet or individual nutrients and pancreatic cancer risk remains unclear. The association between selenium （Se） intake and the risk of pancreatic cancer has been examined by a few observational studies, but remains controversial because of inconsistent results. Therefore, we aimed to conduct this meta-analysis to investigate the association between Se intake and risk of pancreatic cancer. PubMed and Embase databases were searched for observational studies up to May 2017. The summary relative risks （RRs） with 95% confidence intervals （CIs） were calculated with a random-effect model. Final analysis included three cohort studies and three case-control studies. The combined RR of pancreatic cancer for Se intake was 0.76 with a 95% CI of 0.62~0.93. There were no evidence of heterogeneity （P=0.66,I2=0%） and publication bias （Begg′s test： P〉0.1; Egger′s test： P〉0.1）. This meta-analysis provided evidence of a significant inverse association between Se intake and pancreatic cancer.