摘要
长链非编码RNA是非编码RNA家族中的重要成员，其在机体诸多生理病理过程中所发挥的重要调控作用正日益凸显。长链非编码RNAHoTrIP定位于HOXA基因5’末端的长链非编码RNA，目前已发现其在多种消化系统恶性肿瘤中呈异常上调表达并调控肿瘤的发生、发展。本文就消化系统肿瘤中长链非编码RNAHOTVIP调控作用的研究现状进行综述。
As the crucial member of noncoding RNA family, there is increasing evidence that long noncoding RNA has participated in numerous physiological and pathological processes of organisms. HOXA distal transcript antisense RNA is a long noncoding transcript located at the 5＇ tip of HOXA. According to research reports, the up- regulation of HOTTIP is closely associated with occurrence and progression of multiple digestive system cancers and promotes the carcinogenesis. The regulatory effect of long noncoding RNA HOXA distal transcript antisense in digestive system neoplasms will be summarized in this article.
作者
姜兴明
王志东
郑汪洋
李景林
李正龙
李鑫恒
崔云甫
Jiang Xingming Wang Zhidong Zheng Wangyang Li Jinglin Li Zhenglong Li Xinheng Cui Yunfu(Department of Biliary-pancreatic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China)
出处
《国际外科学杂志》
2017年第8期568-572,共5页
International Journal of Surgery
基金
基金项目：国家自然科学基金（81602088）
黑龙江省卫生计生委科研课题（2016049）
哈尔滨医科大学创新科学研究基金（2016LCZX09）
黑龙江省博士后资助课题（LBH-Z16096）
关键词
消化系统肿瘤
预后
综述
长链非编码RNA
HOTTIP
Digestive system neoplasms
Prognosis
Review
Long noncoding RNA
HOXA distal transcript antisense RNA
