孕中期血清学筛查唐氏综合征高风险与不良妊娠结局相关性

Correlation between high risk of Down syndrome and adverse pregnancy outcome in the second trimester of pregnancy

目的探讨和分析孕中期血清学筛查唐氏综合征的高风险与孕妇不良妊娠结局的临床相关性,从而为孕妇不良妊娠结局的临床研究实践提供借鉴和参考依据。方法选取2013年12月至2015年10月期间,来本院行唐氏综合征血清学筛查的孕妇412例为研究对象,根据孕妇唐氏综合征筛查结果对孕妇进行分组,分成了高风险组(151例)和低风险组(261例),观察和比较两组孕妇的不良妊娠结局。结果 (1)高风险组孕妇21-三体发生率为1.99%,低风险组孕妇21-三体发生率为0.00%,高风险组孕妇的21-三体发生率显著高于低风险组,且组间差异具有统计学意义;(2)高风险组孕妇的自然流产率、死胎率和胎盘早剥率均高于低风险组,且组间差异具有统计学意义。结论孕中期血清学筛查唐氏综合征高风险孕妇的不良妊娠结局发生率水平显著升高。

Objective To investigate and analyze the clinical relevance of second trimester serological screening for Down syndrome in pregnant women with high risk of adverse pregnancy outcomes,so as to provide reference basis for clinical practice of maternal adverse pregnancy outcomes.Methods From December 2013 to October 2015,412 cases of pregnant women from our hospital were selected as the research object.According to the pregnant women with Down syndrome screening results,they were divided into high risk group（151cases）and low risk group（261cases）.The bad outcome of pregnancy of two groups were observed and compared.Results（1）High risk pregnant women trisomy 21-incidence rate was1.99%,the low risk group trisomy 21-incidence rate was 0%,the high risk group of pregnant women,trisomy 21-incidence was significantly higher than that in the low risk group,and the difference between groups was statistically significant;（2）High risk pregnant women the incidence of spontaneous abortion,stillbirth rate and the rate of placental abruption was higher than the low risk group,and the difference between groups was statistically significant.Conclusions The incidence of adverse pregnancy outcomes in women with Down syndrome in the second trimester of pregnancy is significantly higher.