胺碘酮与利多卡因治疗急性心肌梗死后室性心律失常临床疗效分析

Clinical analysis of amiodarone and lidocaine in the treatment of ventricular arrhythmias following acute myocardial infarction

目的通过探讨胺碘酮与利多卡因治疗急性心肌梗死后室性心律失常的临床疗效,为临床用药提供理论依据。方法采用回顾性分析方法,以长春市人民医院2015-10至2017-01收治的124例急性心肌梗死后室性心律失常患者为研究对象,按照治疗方法的不同分为对照组(n=62)和观察组(n=62)。对照组给予利多卡因治疗,观察组给予胺碘酮治疗,比较两种给药方案治疗急性心肌梗死后室性心律失常的总有效率及不良反应发生情况。结果经过不同药物治疗后,观察组显效26例、有效33例、无效3例,对照组显效19例、有效30例、无效13例,观察组治疗效果明显优于对照组(Z=-2.134,P=0.033);对照组17例出现不良反应,不良反应率为27.42%;观察组4例出现不良反应,不良反应率为6.45%,观察组不良反应发生率明显低于对照组(χ~2=9.688,P=0.002)。结论采用胺碘酮治疗急性心肌梗死后室性心律失常,不仅可提高治疗总有效率,还可降低药物不良反应,减轻患者痛苦,促进早日康复,提高其生存及生活质量。

Objective The objective of the study was to explore the clinical effectiveness of amiodarone and lidocaine in the treatment of ventricular arrhythmias following acute myocardial infarction （AMI） and provide theoretical basis for clinical medication. Methods A total sample of 124 cases of ventricular arrhythmia following acute myocardial infarction patients between October 2015 and January 2017 admitted to the People＇s Hospital of Jilin Province were retrospectively analyzed. They were divided into control group （n=62） and observation group （n=62） based on the different treatment methods. The control group was treated with lidocaine, while the observation group was treated with amiodarone. The total effective rate and adverse reactions of two groups were compared. Results The observation group showed 26 cases were remarkably effective, 33 cases effective and 3 cases ineffective, while the control group showed 19 cases were remarkably effective, 30 cases effective and 13 cases ineffective, and the degree of effectiveness of the observation group was superior to the control group （Z=-2.134, P=0.033） ; 17 cases in control group occurred adverse reactions and the incidence rate was 27.42%; 4 cases in observation group experienced adverse reactions and the incidence rate was 6.45%, which is lower than that of control group （χ^2=9.688, P=0.002）. Conclusions The use of amiodarone in treatment of ventricular arrhythmias following acute myocardial infarction can not only improve the total effective rate but also reduce the incidence of adverse reactions, relieve the pain of patients, promote recovery and upgrade their survival and life quality.