奥沙利铂联合化疗治疗进展期结肠癌的疗效及血清VEGF、IL-6的变化

Therapeutic effect of L-OHP combined with chemotherapy on the treatment of advanced colon carcinoma and the impact on levels of VEGF and IL-6

目的探讨奥沙利铂(L-OHP)联合化疗治疗进展期结肠癌的临床疗效及对患者VEGF、IL-6水平的影响。方法进展期结肠癌患者117例,采用随机数字法分为治疗组60例与对照组57例;对照组采用亚叶酸钙和5-氟尿嘧啶治疗,治疗组在此基础上加用L-OHP,第一天静脉滴注130 mg/m^2,持续滴注4 h。观察比较两组患者临床治疗效果、不良反应发生情况、VEGF及IL-6水平。结果与对照组相比,治疗组患者完全缓解率(23.33%vs 8.77%)和总有效率(61.67%vs 31.58%)明显较高(P<0.05);同时,治疗组口腔炎(10.00%vs 26.32%)、神经毒性(15.00%vs36.84%)及肾毒性(18.33%vs 43.86%)的发生率也显著降低(P<0.05);治疗后,两组患者的血清VEGF和IL-6水平均显著降低,且治疗组明显低于对照组(P<0.05)。结论 L-OHP联合化疗可有效提高进展期结肠癌患者的临床疗效,不良反应少。

Objective To explore the clinical effect of L-OHP combined with chemotherapy on the treatment of advanced colon carcinoma and the impact on the levels of VEGF,IL-6. Methods 117 cases of advanced colon carcinoma patients were divided into treatment and control groups,control group was treated with CF and 5-FU,and on this basis,the treatment group was treated combined with L-OHP.The clinical therapeutic effect of two groups were observed,the occurrence of adverse reactions and the levels of VEGF and IL-6 were compared.Results Compared with those of control group,the complete remission rate（ 23.33% vs 8.77%） and total effective rate（ 61.67% vs31.58%） in the treatment group were higher（ P〈0.05）. The incidence of stomatitis（ 10.00% vs 26.32%）,neurovirulence（ 15.00% vs 36.84%） and nephrotoxicity（ 18.33% vs 43.86%） in treatment group were lower than those of control group（ P〈0.05）; After the treatment,the levels of VEGF and IL-6 were decreased in the two groups,and the decrease amplitude of the treatment group was significantly higher than that of control group（ P〈0.05）. Conclusions L-OHP combined with chemotherapy can effectively improve the clinical curative effect of advanced colon carcinoma patients,also get fewer adverse reactions and medication safety.