摘要
丹参中含有多种抗乳腺癌的有效成分,其治疗乳腺癌的作用机理成为近年的研究热点。近年来研究表明,丹参有效成分可多靶点、多途径抑制乳腺癌细胞生长增殖,促进细胞凋亡,其作用机制与增殖、凋亡信号传导通路密切相关;丹参在抑制肿瘤迁移和耐药逆转方面也能发挥有效作用。在临床应用中,丹参在改善乳腺癌患者的临床症状和术后并发症、减轻化疗带来的不良反应等方面有显著疗效。
A variety of components in salvia miltiorrhiza are effective in treating breast cancer and its mechanism has become a hot research topic in recent years. Research in recent years showed that effective components in salvia miltiorrhiza could inhibit growth and proliferation of breast cancer cells and promote cell apoptosis by various ways. The mechanism of action is closely related to the signal pathways of cell proliferation and apoptosis. Salvia mihiorrhiza also played an effective role in inhibiting tumor metastasis and reversal of drug resistance. In clinical application, salvia miltiorrhiza has great advantages in improving clinical symptoms, postoperative complications and adverse reactions after chemotherapy of breast cancer patients.
作者
卢迪
赵丕文
赵笛
杨阳
石丹宁
LU Di ZHAO Piwen ZHAO Di et al(School of Life Science, Beijing University of Chinese Medicine,Beijing lO0029,Chin)
出处
《环球中医药》
CAS
2017年第9期1146-1150,共5页
Global Traditional Chinese Medicine
基金
国家自然科学基金(81673764)
关键词
丹参
细胞增殖
细胞凋亡
肿瘤转移
耐药逆转
临床应用
Salvia mihiorrhiza
Cell proliferation
Cell apoptosis
Tumor metastasis
Reversal of drug resistance
Clinical application
