光动力疗法对Louis肺癌鼠的杀伤及免疫效应

Injurious and Immune Effect of Photodynamic Therapy on Mice Bearing Louis Lung Cancer

应用光动力疗法对 30只接种Louis肺癌瘤株的昆明小鼠作杀伤实验研究。对实验组与对照组荷瘤鼠抑瘤曲线、抑瘤率及免疫学指标进行检测。结果表明 ,两组肿瘤生长曲线存在明显差异 (P<0 0 5 )。两组肿瘤生长体积和肿瘤重量均存在明显差异 (P <0 0 1)。实验组瘤体积抑制率为 5 2 94 % ,瘤重量抑制率为 37 2 4 %。各免疫指标与对照组差异有显著性。说明光动力疗法对肿瘤细胞具有杀伤和抑制生长作用 。

The killing experiment via photodynamic therapy (PDT) was carried on 30 Kunming mice inoculated with Louis lung cancer. The tumor suppressing rates and curves were observed between the experimental group and control group. Significant differences in the tumor growth curve (P<0.05), tumor mass and tumor volume existed between the two groups (P<0.01). The tumor suppressing rates of tumor volume and mass were 52.94% and 37.24%, respectively, in the experimental group. The results revealed selective injurious effect and growth suppressing effect of photodynamic therapy (PDT) on tumor cells, it is suggested that PDT can regulate the immune function for the mice inoculated with Louis lung cancer. Photodynamic therapy (PDT) will be a available therapy for malignant tumors.