关于质子泵抑制剂超说明书用药的思考

Off-label use of proton pump inhibitors

超说明书用药是指药品使用的人群与适应证、给药途径与剂量、疗程、联合用药与配伍溶媒等超出说明书规定的情况.质子泵抑制剂(proton pump inhibitor,PPI)是治疗酸相关性疾病最有效的一类药物,已被世界各国广泛使用.国内PPI临床使用量和零售金额都迅猛增长,其中很大一部分是用于预防应激性溃疡,而非治疗酸相关性疾病,说明PPI的超说明书用药现象非常严重.因此,政府有关管理部门、医疗机构、临床医生和药师都应关注PPI的超说明书用药问题.

The off-label use of drugs is that indications, the crowd, route of administration, dosage, course of treatment, or the solvent are not within the range of the label. Proton pump inhibitors（PPIs） are a class of drugs that are most effective for treating acid related diseases and have been widely used worldwide. Theusage amount and retail sales of PPIs have been rapidly growing in China; however, they are often used for the prevention of stress ulcer and not used as therapeutic drugs. This suggests that PPIs abuse is very serious. Therefore, attention from the government, medical institutions, clinicians and pharmacists should be paid to the off-label use of PPIs.