早期肝纤维化MRI分子影像学研究进展

Advances in molecular magnetic resonance imaging of early-stage liver fibrosis

肝纤维化早期诊断,对其治疗及改善预后具有重要意义.目前肝纤维化诊断和分期的"金标准"仍是肝穿刺活检,但因其具有取样误差大、有创等局限性,学术界致力于寻找更准确的无创性诊断方法.目前,还没有一种无创技术能够完全做到对肝纤维化进行早期诊断及准确分期.随着磁共振成像技术的迅速发展,其在肝纤维化严重程度及其发病机制探索等方面展现出良好的应用前景.磁共振分子影像学进行肝纤维化靶向显像,可有助于早期检测肝纤维化,并进行肝纤维化分期.本文主要对肝纤维化早期诊断及分期的分子影像学研究进展作简要综述.

Early diagnosis of liver fibrosis plays a significantrole in treatment decision making and prognosis improvement. Liver biopsy is still the current gold standard to diagnose and stage liver fibrosis, but this procedure has several limitations such as sampling variability and invasiveness. Therefore, there is a pressing need to develop more accurate and noninvasive diagnostic methods. At present,there is no noninvasive technique to diagnose and stage early liver fibrosis accurately. The rapid development of magnetic resonance imaging（MRI） technology suggests good application prospects of this imaging tool in assessing the severity of liver fibrosis and clarifying its pathogenesis. Molecular MRI characterized by target-specific imaging can help detect and stage early liver fibrosis. In this paper, we provide a brief review of new advances in molecular MRI for the diagnosis and staging of early liver fibrosis.