期刊文献+

大疱性类天疱疮180抗体阳性的寻常型天疱疮3例

Three cases of phemphigus vulgaris with anti-Bp180 antibody positive
下载PDF
导出
摘要 报告3例大疱性类天疱疮(BP)180抗体阳性的寻常型天疱疮患者。所有患者均以口腔、外阴黏膜糜烂,躯干多发水疱逐渐加重就诊。皮肤科检查:患者分别在头皮、面部、颈部、口腔、外阴、躯干及下肢等部位出现绿豆至花生米大的孤立或融合性水疱,部分糜烂面潮湿。实验室检查:血清检测抗桥粒芯糖蛋白(Dsg)抗体和Bp180抗体均阳性,直接免疫荧光(DIF)示抗棘细胞桥粒抗体(PCDA)阳性或抗表皮基膜抗体(EBA)阳性。皮损组织病理检查:表皮内水疱,棘细胞松解,基底呈"绒毛"样改变,基底层见中量淋巴细胞浸润。结合临床及实验室检查诊断为BP180抗体阳性的寻常型天疱疮。 Three cases of phemphigus vulgaris with positive anti-BP180 antibody are reported. These patients presented with oral and genital mucosal erosion, and aggravating blisters on the trunk. Physical examination showed isolated and merged blis- ters sized from green bean to peanut on the scalp, face and neck, mouse, external genitalia, chest, back and lower limbs. Some blisters were with erosion. Laboratory tests showed positive for both serum anti-desmoglein(Dsg) and anti-BP180 ant/- body. Direct immunofluorescence(DIF) showed positive for PCDA or EBA antibody. Pathological examination revealed intraepi- dermal blisters, acantholysis, formation of villi by basal cells and lymphocytic infiltrate of the basal layer. Combined the clini- cal features with laboratory results, these patients were diagnosed of phemphigus vulgaris with anti-BPplS0 antibody positive.
出处 《临床皮肤科杂志》 CSCD 北大核心 2017年第10期709-712,共4页 Journal of Clinical Dermatology
关键词 天疱疮 寻常型 BP180 phemphigus vulgaris BP180
  • 相关文献

参考文献4

二级参考文献37

  • 1朱学骏,李冠群.60例天疱疮的皮在固醇激素治疗及预后观察[J].临床皮肤科杂志,1993,22(4):190-192. 被引量:13
  • 2顾艳,郑捷.T细胞介导的细胞免疫在寻常型天疱疮中的作用[J].上海交通大学学报(医学版),2007,27(4):457-460. 被引量:2
  • 3Carson PJ,Hameed A,Ahmed AR.Influence of treatment On the clinical ourse of pemphigus vulgaris.J Am Acad Dennatol 1996;34:645-652.
  • 4Bystryn JC, Steinman NM. The adjuvant therapy of pemphigus. An update. Arch Dermatol 1996; 132:203-212.
  • 5Amano H, Mofimoto S, Kaneko H, et al. Effect of intravenous cyclophosphamide in systemic lupus erythematosus: relation to lymphocyte subsets and activation markets. Lupus 2000;9:26-32.
  • 6Pandya AG, Sontheimer. Treatment of pemphigus vulgaris with pulse intravenous cyclophosphamide. Arch Dennatol 1992; 128: 1626-1630.
  • 7Fu LW, Yang LY, Chen WP, et al. Clinical efficacy of nephritis with heavy proteinuria. Br J Rheumatol 1998: 37: 217-221.
  • 8Roberto Glorio,Graciela Rodriguez Costa,Roxana Haas,Mijail Gruber,Leonardo Fainboim,Alberto Woscoff.HLA Haplotypes and Class II Molecular Alleles in Argentinian Patients with Pemphigus Vulgaris[J]. Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology . 2002 (5)
  • 9Meyer N,Misery L.Geoepidemiologic considerations of auto-immune pemphigus. Autoimmunity Reviews . 2010
  • 10Tunca M,Musabak U,Sagkan RI,et al.Association of humanleukocyte antigen class II alleles with pemphigus vulgaris in aTurkish population. Journal of Dermatology . 2010

共引文献68

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部