紫外线照射治疗蕈样肉芽肿的不良反应观察

Observation of adverse reactions in the treatment of mycosis fungoides with phototherapy

目的:观察紫外线治疗蕈样肉芽肿过程中出现的急性及慢性不良反应。方法:用问卷方式回顾性研究紫外线照射治疗73例蕈样肉芽肿过程中引起的急性及慢性不良反应。结果:照射紫外线急性不良反应包括皮肤干燥(60例)、瘙痒(37例)、红斑(15例)、水肿(8例)。慢性不良反应有光化性黑子(47例)、色素沉着(65例)、色素脱失(27例)、光老化(10例)、皮肤癌变(1例)。结论:长期紫外线照射治疗安全性好,不良反应少并可以耐受。

Objective： To observe acute and chronic adverse reactions in the treatment of mycosis fungoides with the ultravi- olet irradiation. Methods： A retrospective study was performed by questionnaire surveys to evaluate acute and chronic side effects in 73 patients with MF treated with ultraviolet irradiation. Results： Acute adverse reactions to ultraviolet irradiation included dry skin （60 cases）, pruritus（37 cases）, erythema（15 cases） and edema（8 cases）, while chronic adverse reactions included lentigo（47 cases）, hyperpigmentation（65 cases）, depigmentation（27 cases）, photoaging（10 cases） and skin carcino- genesis（1 case）. Conclusions： The long-term ultraviolet irradiation is tolerable and safe with fewer adverse reactions.