肿瘤细胞发生有丝分裂灾难分子机制的研究进展

Research progress on the molecular mechanism of mitotic catastrophe in tumor cells

有丝分裂灾难是一种新的细胞死亡形式,是有丝分裂过程失调而发生的细胞死亡现象,是一个真正意义上的内源性肿瘤抑制机制。然而,尽管有丝分裂灾难在预防和治疗肿瘤中具有重要意义,但其发生的分子机制尚未清晰阐明。本文探讨肿瘤细胞发生有丝分裂灾难机制最新的研究进展,为肿瘤细胞发生有丝分裂灾难机制的进一步研究提供参考依据。

Mitotic catastrophe is a new form of cell death,which is the phenomenon of cell death caused by the disorder of mitosis. It is a true endogenous mechanism of tumor suppression. However,although mitotic catastrophe is important in the prevention and treatment of tumors,the molecular mechanism of its occurrence has not been clearly elucidated.In this paper,we will discuss the latest research progress on the mechanism of mitotic catastrophe in tumor cells,and provide a reference for further study on the mechanism of mitosis catastrophe.