女性高血压患者血清G蛋白耦联雌激素受体的水平

The level of G protein-coupled estrogen receptor in female patients with hypertension

目的观察女性高血压患者血清G蛋白耦联雌激素受体(GPER)水平的变化。方法采用1∶1配对病例对照研究,以2015年7-11月在苏州大学附属第二医院体检的女性为研究对象,调查高血压者和正常血压者共502对,测量血压、身高、体质量和腰围,问卷收集吸烟、饮酒、家族史等情况,检测血脂、血糖、尿酸和血清GPER等指标。采用单因素和多因素条件Logistic回归方法,进行血清GPER水平与女性高血压的关联性分析。结果高血压组的血清GPER水平低于正常血压组[125.08(92.39,169.56)比143.61(94.76,207.82)ng/L,P<0.05]。条件Logistic回归模型显示,调整多因素后,血清GPER水平和高血压存在关联性(OR=0.800,95%CI 0.696,0.919)。在未绝经女性中,血清GPER水平与高血压没有关联(P>0.05);在绝经女性中,与最低四分位者相比,血清GPER水平处于最高四分位者患高血压的危险性是0.474倍(95%CI 0.287,0.785),且随血清GPER水平的升高,患高血压的危险性下降(趋势检验P<0.05)。结论在绝经女性人群中血清GPER水平与高血压有关联。

Objective To investigate the level of G protein-coupled estrogen receptor {GPER） in females with hypertension. Methods This was a pair matched case-control study, which included 502 pairs of women with or without hypertension, who received health checkup in the Second Affiliated Hospital of Soochow University between July and November 2015. Blood pressure, height, body weight and waist circumference were measured. Informations such as smoking, drinking and family history of hypertension were assessed based on questionnaire. And blood glucose, lipid, uric acid, serum GPER were tested. The association between GPER and hypertension were ana- lyzed by univariate and multivariate Logistic regression. Results The mean level of GPER in hypertensives was significantly lower than normotensive females [125.08 （ 92.39, 169.56 ） vs 143.61 （ 94.76, 207.82 ） ng/L, P〈 0. 05]. Multivariate Logistic regression analysis showed GPER was associated with hypertension after adjustment for confounders （OR=0. 800, 95% CI 0. 696, 0. 919}. However, there was no association between GPER and hy- pertension in pre-menopausal women [P^0. 05）. In the post-menopausal women, the risk of hypertension in the hightest quartile of GPER was lower than those in the lowest quartile of GPER （OR=0. 474, 95% CI：0. 287, 0. 785）, moreover, the risk of hypertension decreased along with the increase of GPER level（P for trend〈0. 05 ）. Conclusion The serum GPER level was associated with hypertension in post-menopausal women.