舒芬太尼不同给药方式全麻诱导对手术患者呛咳反应的影响

Effect of Sufentanil Induced by General Anesthesia on Cough Response in Patients Undergoing Surgery

目的探析舒芬太尼不同给药方式进行全麻诱导插管对患者呛咳反应的影响。方法选择2014年1月—2016年12月在我院接受全麻气管内插管术患者200例。按照舒芬太尼不同浓度及给药速度随机将入选者分成A组(常规注射,浓度5μg/ml,10 s注完,64例)、B组(稀释浓度2.5μg/ml,快速注射,5 s注完,66例)和C组(稀释浓度2.5μg/ml,慢速注射,20 s注完,70例)。比较3组患者的一般资料、呛咳反应情况及不同时间点血流动力学指标水平。结果 3组患者的一般资料对比,差异无统计学意义(P>0.05)。C组患者的呛咳反应时间明显高于A、B组,总发生率4.3%,低于A组(46.9%)、B组(48.5%),严重程度也明显比A、B组低(P<0.05);A、B组间呛咳反应时间、总发生率及严重程度对比,差异无统计学意义(P>0.05)。3组患者在各时间点的MAP、HR及SpO_2水平均无变化(P>0.05)。结论舒芬太尼稀释、慢速注射的给药方式行全麻诱导可明显减缓患者出现呛咳反应的时间、降低其发生率及严重程度。

Objective To investigate the effect of sufentanil on the cough response induced by general anesthesia induction intubation.Methods From January 2014 to December 2016,200 patients with tracheal intubation under general anesthesia in our hospital were selected.According to the different concentration of sufentanil and the speed of administration,they were randomly divided into A group（routine injection,concentration 5 μg/ml,10 s injection,64 cases）,group B（diluted concentration of 2.5 μg/ml,rapid injection,5 s injection,66 cases） and group C（dilution concentration 2.5 μg/ml,slow injection,20 sinjection,70 cases）.The genera ldata,cough reaction and hemodynamic indexes at different time points were compared between the 3 groups.Results There was no significant difference between the 3 groups in general data（P〈0.05）.The cough response time of group C was significantly higher than that of group A and group B,overall incidence was 4.3%,lower than A（46.9%） and B（48.5%）,The severity was also significantly lower than that in group A and group B（P〈0.05）;There was no significant difference in cough reaction time,total incidence and severity between A and B（P〈0.05）.There were no changes in MAP,HR and SpO_2 levels at each time point in the 3 groups（P〈0.05）.Conclusion Sufentanil,diluted,slow injection administration,general anesthesia induction can significantly reduce the occurrence of cough reaction time,reduce the incidence and severity.