甲氨蝶呤与来氟米特治疗类风湿性关节炎的临床疗效分析

Clinical Efficacy of Methotrexate and Leflunomide in the Treatment of Rheumatoid Arthritis

目的分析针对类风湿性关节炎采用甲氨蝶呤与来氟米特治疗的临床效果。方法选择本院2016年4月—2017年1月收治的106例类风湿性关节炎患者进行观察,将患者分为对照组和实验组,两组分别53例;对照组患者予以甲氨蝶呤进行治疗,实验组则予以甲氨蝶呤联合来氟米特进行治疗,而后对比两组患者治疗的临床效果。结果对照组患者治疗的总有效率为79.25%,总不良反应率为86.79%,实验组患者治疗总有效率为96.23%,总不良反应率为66.04%,差异具有统计学意义(P<0.05)。结论采用甲氨蝶呤与来氟米特治疗类风湿性关节炎,可有效提升治疗效果,且不良反应率也可得到相应的降低,因此可在临床中采用该方法治疗类风湿性关节炎。

Objective To analyze the clinical effects of methotrexate and leflunomide on rheumatoid arthritis.Methods Selected 106 patients with rheumatoid arthritis treated from April 2016 to January 2017 in our hospital,they were divided into the control group and the experimental group,each group had 53 cases;the control group were treated with methotrexate,experimental group was treated with methotrexate combined with leflunomide,then the clinical effects of the two groups were compared.Results The total effective rate of the control group was 79.25%,and the total adverse reaction rate was 86.79%,the total effective rate of the experimental group was 96.23%,the total adverse reaction rate was 66.04%,the difference was statistically significant（P〈0.05）.Conclusion Treatment of rheumatoid arthritis with methotrexate and leflunomide can effectively improve the therapeutic effect,and the rate of adverse reactions can be reduced accordingly,so this method can be used in clinical treatment of rheumatoid arthritis.