新型立体IUD研制及猕猴实验初步研究

Development of a new stereoscopic intrauterine device and the preliminary experimental study performed with rhesus macaque

目的:研制并观察猕猴应用立体网状镍钛记忆合金宫内节育器(SIUD)后的避孕效果,为避孕节育提供新的方法及实验数据。方法:SIUD支架为心形或倒梨形,用镍钛记忆合金丝编织成网格状支架,外包硅橡胶。成年雌性猕猴分为手术放置SIUD组(实验组)和假手术组(对照组)各9只,分别开腹进行子宫、卵巢外部测量,并观察放置SIUD避孕效果。结果:猕猴用9只猕猴通过宫底穿刺用放置器顺利放置新型IUD,3个月时1只猕猴SIUD脱落后妊娠,其余8只未脱落均未妊娠;对照组9只均妊娠,两组差异有统计学意义(P=18.452,t=0.000)。结论:猕猴子宫形状与人类相似度高,是研制新型SIUD的较好动物模型,猕猴用SIUD具有较好的避孕效果。

Objective：To develop a new stereoscopic intrauterine device（SIUD）for rhesus macaque,and to further provide the new contraception and experimental data for women birth control.Methods：The stent of rhesus macaque SIUD was heart-shaped or inverted pear-shaped,and was made from nickel-titanium memory alloy wires and was covered the layer of silicone rubber.The shape of SIUD was designed as three-dimensional network structure.Adult male rhesus macaques were selected and divided into SIUD experimental group（n=9）and control group（n=9）.The entire male rhesus macaques were measured their uterus and ovary after laparotomy.And after laparotomy,the SIUD was inserted into the exposed uterus of rhesus macaques in SIUD experimental group.Results：,In experimental group,nine monkeys were successfully inserted a SIUD through uterine bottom puncture,and only one monkey＇s SIUD was expulsed and became pregnant（11.1%,1/9）after 3months.9monkeys in control all became pregnant（P=18.452,t=0.000）.Conclusion：The shape of uterus of rhesus macaque is similar to that of human beings,so rhesus macaque is a good animal model for the development of new SIUD.Rhesus monkey SIUD has good contraceptive effects.