自拟补肾活血汤治疗慢性肾小球肾炎的疗效观察

Clinical Observation on Chronic Glomerulonephritis by Bushen Hoxue Decoction(自拟补肾活血汤)

目的:探讨自拟补肾活血汤治疗慢性肾小球肾炎的疗效。方法:将82例慢性肾小球肾炎患者随机分为对照组和治疗组,对照组41例予以临床常规治疗,治疗组41例在临床常规治疗基础上联用自拟补肾活血汤治疗,观察并记录患者中医证候评分、肾功能指标,同时对比两组临床疗效及并发症。结果:对照组总有效率(70.7%)低于治疗组(90.2%),差异有统计学意义(P<0.05)。与治疗前比较,两组治疗后中医证候评分、肾功能指标均降低。治疗后两组比较,治疗组中医证候积分均低于对照组;治疗组治疗后血肌酐、血清尿素氮、24 h尿蛋白含量、1 h尿红细胞排泄率均低于对照组,差异均有统计学意义(P<0.05);两组患者不良反应轻微,经相应处理或自行缓解,对患者或研究无影响。结论:采用自拟补肾活血汤治疗慢性肾小球肾炎疗效确切,能缓解临床症状,改善肾功能。

Objective： To investigate the clinical effect of Bushen Hoxue Decoction on chronic glomerulonephritis. Methods： The 82 patients with chronic glomerulonephritis were divided into two groups randomly. The 41 patients in control group were treated with routine treatment, and the 41 patients in treatment group were treated by Bushen Hoxue Decoction on the base of the control group. The TCM syndrome score and renal function indexes were recorded and clinical efficacy and complications were compared. Results： The effective rate in the control group （70.7%） was lower than the treatment group （90.2%）, with significant difference （P〈0.05）. The TCM symptoms score and renal function indexes decreased in the two groups after treatment, and the treatment group showed lower TCM syndrome score than the control group; The treatment group showed lower serum creatinine, serum urea nitrogen, 24 h urinary protein content, and 1 h urinary red blood cell excretion rate than the control group, with significant difference （P〈0.05）. The adverse reactions were mild in the two groups, and there was no influence on the patients or the study, with the corresponding treatment or self remission. Conclusion： Bushen Hoxue Decoction can provide accurate curative on chronic glomerulonephritis; it can alleviate clinical symptoms and improve renal function.