扶正化纤散防治正虚血瘀型乙型肝炎后肝纤维化临床研究

Clinical Research on Fuzheng Huaxian Powder for the Prevention and Treatment of Post-Hypertitis B Hepatic Fibrosis of Syndrome of Healthy Qi Deficiency and Blood Stasis

目的:观察扶正化纤散防治正虚血瘀型乙型肝炎(简称乙肝)后肝纤维化的临床疗效。方法:选取2014年9月—2015年12月在本院诊治的正虚血瘀型乙肝后肝纤维化患者80例,随机分成观察组与对照组,每组40例。对照组给予还原型谷胱甘肽片治疗,每次口服0.4 g,每天3次。观察组给予扶正化纤散治疗,将所有药物打制成粉末状,并装入胶囊中口服,每次3 g,日3次。结果:治疗后,两组患者层黏蛋白、Ⅲ型前胶原、Ⅳ型胶原水平比较,无统计学意义(P>0.05),观察组治疗后血清透明质酸优于对照组(P<0.05),有统计学意义;观察组治疗后谷丙转氨酶、谷草转氨酶水平优于对照组(P<0.05),有统计学意义;观察组有效率为97.5%,对照组有效率为67.5%,观察组优于对照组(P<0.05)。结论:扶正化纤散治疗正虚血瘀型乙肝后肝纤维化疗效显著,能改善患者的肝功能、肝纤维化。

Objective： To observe the clinical effects of Fuzheng Huaxian Powder for the prevention and treatment of post-hypertitis B hepatic fibrosis of syndrome of healthy qi deficiency and blood stasis. Methods： Totally 80 patients with post-hypertitis B hepatic fibrosis of syndrome of healthy qi deficiency and blood stasis treated in this hospital between September 2014 and December 2015 were randomized into observation group and control group,40 cases in each group. Control group were given oral administration of Reduced Glutathione Tablets,0. 4 g each time and 3 times a day while observation group were given oral administration of Fuzheng Huaxian Powder for the treatment,3g each time and 3 times a day. Results： After treatment,there was no statistical significance between the two groups in the levels of mucoprotein,typeⅢprocollagen and typeⅣcollagen（ P〈0. 05）. The levels of hyaluronic acid in the serum,ALT and SGOT in observation group were superior to those in control group（ P〉0. 05）. The effective rate was 97. 5% in observation group and 67. 5% in control group（ P〈0. 05）. Conclusion： Fuzheng Huaxian Powder has significant therapeutic effects on post-hypertitis B hepatic fibrosis of syndrome of healthy qi deficiency and blood stasis,which can improve the liver function and hepatic fibrosis.