滋阴解毒化瘀方对系统性红斑狼疮患者临床疗效及免疫功能的影响

Effects of Yin-Nourishing Toxicity-Eliminating and Blood Stasis-Resolving Prescription on Systemic Lupus Erythematosus and Patients' Immunity

目的:观察滋阴解毒化瘀方对系统性红斑狼疮患者临床疗效及免疫功能的影响。方法:选择2013年4月—2015年6月在本院治疗的确诊为系统性红斑狼疮的患者76例,随机分为对照组和观察组,每组38例。对照组给予泼尼松治疗,观察组在对照组治疗的基础上加用自拟滋阴解毒化瘀方治疗。结果:两组患者治疗后中医证候积分与治疗前比较,均有显著改善(P<0.05),且观察组治疗后优于对照组(P<0.05);两组起效时间和皮损消退时间比较,观察组均优于对照组(P<0.05);观察组治疗后血清CD4、CD8及CD4/CD8水平优于对照组(P<0.05);对照组有效率73.7%,观察组有效率94.7%,观察组优于对照组(P<0.05)。结论:滋阴解毒化瘀法治疗系统性红斑狼疮,可有效改善患者的临床症状,改善免疫功能,效果显著。

Objective： To observe the effects of Yin-Nourishing Toxicity-Eliminating and Blood Stasis-Resolving Prescription on systemic lupus erythematosus（ SLE） and patients＇ immunity. Methods： Totally 76 patients diagnosed with SLE treated in Puyang Oilfield General Hospital between April 2013 and June 2015 were randomized into control group and observation group,38 cases in each group. Control group were given Prednison while observation group were added with Yin-Nourishing Toxicity-Eliminating and Blood Stasis-Resolving Prescription for the treatment. Results： The TCM symptom scores in both groups after treatment improved significantly（ P〈0. 05）,and observation group were superior to control group（ P〈0. 05）. For the medical effect onset time and fading time of skin lesion,the improvement in observation group was superior to that in control group（ P〈0. 05）. The levels of CD4,CD8 and CD4/CD8 in observation group were superior to those in control group（ P〈0. 05）. The effective rate was 94. 7%in observation group and 73. 7% in control group; observation group were superior to control group（ P〈0. 05）. Conclusion： YinNourishing Toxicity-Eliminating and Blood Stasis-Resolving Prescription can significantly improve the clinical effects on SLE and SLE patients＇ immunity.