摘要
目的探讨高强度聚焦超声(high intensity focused ultrasound,HIFU)无创疗法联合米非司酮治疗子宫腺肌症的效果。方法选取2015年10月—2017年1月因子宫腺肌症行HIFU治疗的患者110例。根据治疗方法分为观察组和对照组,每组55例。对照组单纯采用HIFU治疗,观察组在对照组基础上加用米非司酮治疗。观察并比较两组的子宫体积变化、临床疗效、临床症状改善及不良反应情况。结果两组治疗后6个月子宫体积均小于治疗前(P<0.05)。两组在治疗后1个月、3个月、6个月时病灶体积均小于治疗前(P<0.05);在相同时间点两组病灶体积、病灶消融率比较差异均无统计学意义(P>0.05)。治疗后12个月,两组月经量均少于治疗前(P<0.05),观察组月经量少于对照组(P<0.05)。治疗后12个月,观察组痛经程度较治疗前明显改善(P<0.05)。观察组临床疗效总有效率高于对照组(P<0.05)。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论单纯HIFU无创疗法或HIFU联合米非司酮治疗子宫腺肌症安全有效,均能有效缩小病灶体积,改善临床症状,但后者疗效果更佳。
Objective To investigate effect of noninvasive high intensity focused ultrasound (HIFU) combined with Mifepristone in treatment of patients with adenomyosis. Methods A total of 110 patients with adenomyosis undergo- ing HIFU during October 2015 and January 2017 were selected, and the patients were divided into observation group (n=55) and control group (n=55) according to therapeutic methods. Control group was treated with HIFU alone, while observation group was added with Mifepristone on the basis of treatment for control group. Changes of uterine vol- ume, clinical efficacy, improvement conditions of clinical symptoms and adverse reactions were observed and Compared between the two groups. Results In the two groups, after treatment for 6 months, values of uterine volume were less than those before treatment (P 〈 0.05) ; after treatment for 1 month, 3 months and 6 months, values of lesion volume were less than those before treatment ( P 〈 0.05). There were no significant differences in lesion volume and ablation rate at the same time point between the two groups (P 〉 0.05). After treatment for 12 months, values of menstrual volume were less than those before treatment in two groups (P 〈 0.05) ; value of menstrual volume in observation group was less than that in control group after treatment for 12 months than that before treatment (P 〈 0.05) ; the dysmenorrhea degree in observation group was significantly improved (P 〈 0. 05). The total effective rate in observation group was significantly higher than that in control group (P 〈 0.05). There was no significant difference in total incidence rate of adverse reac- tions between the two groups (P 〉 0. 05). Conclusion Both noninvasive HIFU therapy and HIFU combined with Mife- pristone in treatment of patients with adenomyosis can effectively decrease lesion volume and improve clinical symptoms, but HIFU combined with Mifepristone can achieve better effect.
作者
时玲玲
杨秀梅
朱丽华
SHI Ling-ling YANG Xiu-mei ZHU Li-hua(Department of Obstetrics and Gynecology Department of Ultra- sonics, People's Hospital of Cangzhou City, Gangzhou, Hebei 061000, China)
出处
《解放军医药杂志》
CAS
2017年第9期17-21,共5页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
沧州市科技计划项目(151302031)
关键词
高强度聚焦超声
子宫腺肌症
米非司酮
High intensity focused ultrasound
Adenomyosis
Mifepristone