血清CEA、PGR、G-17检测在胃癌诊断中的价值分析

Analysis on the value of serum CEA,PGR and G-17 in the diagnosis of gastric cancer

目的观察和分析血清癌胚抗原(CEA)、胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ比值(PGR)、促胃液素17(G-17)检测在胃癌诊断中的价值。方法选取200例胃癌患者作为病例组,选取100例胃黏膜正常或轻度非萎缩性胃炎患者作为对照组。对两组患者的血清CEA、PGR、G-17水平进行检测和比较。结果病例组患者的血清CEA水平和G-17水平显著高于对照组,PGR水平显著低于对照组,两组之间差异均有统计学意义(P<0.05)。进展期胃癌患者的血清CEA、G-17水平显著高于早期胃癌患者或对照组研究对象,PGR显著低于早期胃癌患者或对照组研究对象,早期胃癌患者的血清G-17水平显著高于对照组研究对象,差异均有统计学意义(P<0.05)。胃窦癌患者的血清PGR水平显著高于胃体癌患者,胃体癌患者的血清PGR水平显著高于近端胃癌患者,胃体癌患者的血清G-17水平显著高于近端胃癌患者,近端胃癌患者的血清G-17水平显著高于胃窦癌患者,差异均有统计学意义(P<0.05)。结论胃癌患者表现为血清CEA、G-17水平的上升和PGR水平的下降,三种血清学标志物对于胃癌的诊断具有辅助价值,而且血清G-17和PGR检测还可用于辅助胃癌的早期诊断和病变部位诊断。

Objective To observe and analyze the value of serum carcinoembryonic antigen （CEA）, pepsinogen I / pepsinogen II ratio （PGR） and gastrin 17（G-17） in the diagnosis of gastric cancer. Methods 200 cases of patients with gastric cancer were selected as the case group, 100 cases of patients with normal gastric mucosa or non atrophic gastritis were selected as the control group. The serum CEA,PGR,G--17 levels of the patients in the two groups were detected and compared. Results The serum CEA and G-17 levels of the patients in the case group were significantly higher than those in the control group, the level of PGR was significantly lower than that in the control group, the differences between the two groups were statistically significant （P〈0.05）. The serum CEA, G-17 levels of the patients with progressive gastric cancer were significantly higher than those of the patients with early gastric cancer or the subjects in the control group. PGR was significantly lower than that of patients with early gastric cancer or the subjects in the control group. The serum G-17 level of the patients with early gastric cancer was significantly higher than that in the control group,the difference was statistical significant （P〈0.05）. The serum PGR level in patients with gastric antrum cancer was significantly higher than that in patients with gastric cancer, the serum PGR level in patients with gastric cancer was significantly higher than that of the patients with proximal gastric cancer. The serum G-17 level of the patients with gastric cancer was significantly higher than that of the patients with proximal gastric cancer. The serum G-17 level of the patients with proximal gastric cancer was significantly higher than that of patients with gastric antrum cancer, the differences were statistically significant （P〈0.05）. Conclusion The gastric cancer patients show the increased levels of serum CEA and G-17 as well the decreased level of PGR. Such three kinds of serological markers have auxiliary value for the diagnosis of gastric cancer. The serum G-17 and PGR detection can also be used to assist the early diagnosis and lesion diagnosis of gastric cancer.