临界可切除胰腺癌的诊疗策略

Diagnosis and treatment strategies for borderline resectable pancreatic cancer

胰腺癌早期诊断困难,80%的患者就诊时已发生局部进展或远处转移。目前,手术切除仍是胰腺癌患者获得长期生存的唯一方法。近年来,胰腺癌综合治疗水平较前有所提高。针对临界可切除胰腺癌进行新辅助治疗,可以达到降期,甄别人群,筛选潜在获益人群进行手术的目的。合理选择有效化疗方案,恰当选择手术时机,能进一步提高胰腺癌的切除率,从而延长该类高危人群的生存期。

Pancreatic cancer is difficult to diagnose at an early stage, with about 80% of patients having local invasion or distant metastasis at the initial consultation. At present, surgical resection remains the only hope for long- term survival in patients with pancreatic cancer. The level of comprehensive treatment of pancreatic cancer has somewhat improved over the past few years. In borderline resectable pancreatic cancer, the use of neoadjuvant therapy may achieve the goal of tumor downstaging, and screening and selecting potential patients for surgery. Proper selection of chemotherapy regimen and appropriate choice of surgery timing can further improve the resection rate of pancreatic cancer~ and thereby prolong the survival time in this high-risk population.