低氧对间充质干细胞旁分泌信号的调节（英文）

Hypoxia modulates paracrine signaling in mesenchymal stem cells

间充质干细胞(mesenchymal stem cells,MSCs)是一类多功能干细胞,在细胞治疗和再生医学领域受到研究者的极大关注。最近在MSCs的旁分泌机制和细胞因子对MSCs的调控方面取得的重大研究进展提示,MSCs在临床应用方面具有多种潜能。例如,低氧从多方面影响MSCs功能(细胞周期,细胞分化,旁分泌信号通路和基因表达)。MSCs构建细胞龛调节细胞局部微环境是通过复杂的分泌细胞因子方式实现的,这使得我们对MSCs的认识取得了巨大飞跃。这篇综述集中在上述研究进展上,尤其是低氧条件下MSCs对旁分泌信号通路的调节。除此之外,本文还回顾了近期关于间充质干细胞相关的重要细胞因子和它们在体内、体外作用的相关研究。

Objective Mesenchymal stem ceils（MSCs） are adult muhipotent cells of great interest in the areas of regenerative medicine and cell therapy.Recent advances in understanding of the paracrine mechanisms and cyto- kine modulation of MSCs suggest many potential clinical applications.For example, hypoxia affects several MSC ac- tivities, including the cell cycle, differentiation, paracrine signaling , and gene expression.Our understanding of MSCs has taken great strides forward, even to the creation of their niche by a complex of secreted cytokines.This review fo- cuses on these advances, especially regarding the modulation of paracrine signaling by MSCs in hypoxic conditions. In addition,we have summarized recent studies on important MSC-related cytokines and their effects in vitro and in vivo.