PRKAA1和PSCA基因多态性与胃癌相关性研究新进展

New progress of the association of gene polymorphisms of PRKAA1 and PSCA with gastric cancer

胃癌是消化系统最常见恶性肿瘤之一,死亡率高。目前全基因组关联研究(genome-wide association study,GWAS)发现多个基因的单核苷酸多态性(single nucleotide polymorphism,SNP)与胃癌相关,其中位于PRKAA1上的rs13361707、rs10074991、rs154268、rs3805486、rs6882903和rs10036575多态性与胃癌易感性相关,该基因在机体能量代谢,细胞生长增殖、凋亡、自噬等方面具有重要作用。PSCA基因编码产物可抑制肿瘤生长,rs2294008、rs2976392等位点多态性与胃癌风险增加相关。本文就PRKAA1和PSCA基因多态性与胃癌相关性研究新进展作一概述。

Gastric cancer is one of the most common malignant cancers, with a high mortality rate. Genome-wide association study （GWAS） has identified multiple single nucleotide polymorphisms （SNP） in various genes which are related with gastric cancer. Among them, rs13361707, rs10074991, rs154268, rs3805486, rs6882903 and rs10036575 in PRKAA1 gene are associated with the susceptibility of gastric cancer. The encoding product of PRKAAI plays an im- portant role in energy metabolism, cellular growth, proliferation, apoptosis and autophagy. PSCA can inhibit proliferation of gastric cancer cells. The variation of rs2294008 and rs2976392 in PSCA can increase the gastric cancer risk. In this paper, we reviewed the recent progress of the association of gene polymorphisms of PRKAA1 and PSCA with gastric cancer,