胃食管反流病诊断新进展—非侵入性唾液胃蛋白酶检测

Progress of the methods for diagnosis of gastroesophageal reflux disease—noninvasive saliva pepsin detection

胃食管反流病(gastroesophageal reflux disease,GERD)是胃、十二指肠内容物反流入食管引起临床不适症状和(或)食管黏膜组织学改变的一类疾病,主要表现为反酸、烧心、咽喉炎等症状,临床上对于该病的诊断也存在一些问题。近年来,随着对GERD的深入研究,其临床诊断方法也呈现多样化,本文将就目前几种常用的临床诊断方法的新进展进行综述,并对未来可能应用于临床的非侵入性唾液胃蛋白酶检测方法作一概述。

Gastroesophageal reflux disease （GERD） is attributed to the content of stomach and duodenum against to esophagus, causing clinical symptoms and/or histologic changes of esophageal mucosa, mainly characterized by acid regurgitation, heartburn, sore throat and other uncomfortable symptoms. There are still some problems to confirm or eliminate the disease in clinic. In recent years, with the in-depth study of GERD, diversifide clinical diagnostic methods have been proposed. In this paper, the new progress of several commonly used diagnostic methods was reviewed, at the same time, the research trend of the noninvasive saliva pepsin detection being used to clinic in the future was introduced.