2型糖尿病患者甘油三酯与心肌梗死的相关性研究

To research the correlation between triglyceride and myocardial infarction in patients with type 2 biabetes mellitus

目的:从心肌梗死危险因素角度探讨与甘油三酯相关的心血管剩留风险。方法:回顾性分析2016年2月—2016年7月收治的符合低密度脂蛋白胆固醇(LDL-C)<2.0 mmol/L的2型糖尿病患者218例,其中合并心肌梗死组112例,无心肌梗死组106例(对照组),研究两组部分生化指标及病史。结果:观察组饮酒史、高血压史、总胆固醇(TC)、甘油三酯(TG)、体质量指数均高于对照组(P<0.05),而高密度脂蛋白胆固醇(HDL-C)低于对照组(P<0.05),差异有统计学意义。对心肌梗死采用多因素逐步Logistic回归分析,结果显示高血压、胆固醇、甘油三酯是心肌梗死的危险因素。结论:甘油三酯为心肌梗死的独立危险因素,在LDL-C正常的2型糖尿病患者中,当合并有高甘油三酯血症时,仍有发生心肌梗死的心血管剩留风险存在。

Objective：To analyze the correlation between triglyceride and myocardial infarction in patients with type 2 diabetes mellitus,and to further investigate the residual risks of cardiovascular events associated with triglyceride from the perspective of risk factors for myocardial infarction.Methods：A total of 218 patients with type 2 diabetes mellitus with low density lipoprotein cholesterol（LDL-C）2.0 mmol/L at this hospital were enrolled in this retrospective study from February 2016 to July 2016,including the group of 112 patients combined with myocardial infarction,the group of 106 patients without myocardial infarction as the control group,to study the medical histories and some biochemical indexes between the two groups.Results：The history of smoking,drinking history,history of hypertension,total cholesterol（TC）,triglyceride（TG）,body mass index were significantly higher in the group of type 2 diabetes mellitus patients combined with myocardial infarction than in the control group（P〈0.05）,the difference of high density lipoprotein cholesterol（HDL-C） lower than that of the control group（P〈0.05） were statistically significant;multivariate stepwise Logistic regression on the myocardial infarction cases,the result showed that hypertension,cholesterol,and triglyceride were risk factors of myocardial infarction.Conclution：Triglyceride is an independent risk factor for myocardial infarction,when combined with hypertriglyceridemia,there is still a residual risks of cardiovascular events of myocardial infarction in type 2 diabetic patients with normal LDL-C level.