中性粒细胞CD64的表达在感染性疾病中的诊断价值

Neutrophil CD64 expression as a biomarker in the diagnosis of infectious disease

感染性疾病是威胁人类健康的杀手之一，缺乏早期特异性及快速诊断指标是导致严重感染性疾病病死率增高的原因之一。近年来，越来越多的研究结果显示中性粒细胞CD64的表达对感染性疾病的早期诊断有较好的诊断价值，联合外周血白细胞计数（WBC）、C反应蛋白（CRP）、降钙素原（PCT）等其他炎症指标，可提高感染性疾病早期诊断的特异性及敏感性。

Infectious Diseases is one of the leading killers of human being worldwide. The lack of specific index for early diagnosis is one of the factors accounting for the increased mortality in the severe infectious disease. For the past few years, there is growing evidence that neutrophil CD64 expression is of diagnostic value in infectious disease, which may improve the sensitivity and specificity in diagnosing infectious disease when combined with other inflammatory biomarkers such as white blood cell count （WBC）, C-reactive protein （CRP） and procalcitonin （PCT）.