期刊文献+

MAWBP在炎症性肠病中的表达及特征

下载PDF
导出
摘要 目的探讨MAWBP在炎症性肠病(IBD)中的表达及特征。方法随机收集进行结肠镜的患者肠道标本和临床资料共159例,其中溃疡性结肠炎(UC)患者77例,克罗恩病(CD)患者22例,正常人60例。免疫组织化学染色检测肠道MAWBP表达情况,分析MAWBP表达量与IBD患者临床资料的相关性。结果 MAWBP阳性率在IBD患者中低于正常人;MAWBP表达量与UC临床分级相关,轻度患者对应较高表达量,中重度患者对应较低表达量。结论 MAWBP在IBD中表达下调,MAWBP在IBD中可能具有抑制炎症和癌变作用。
出处 《广东医学》 CAS 北大核心 2017年第18期2790-2792,共3页 Guangdong Medical Journal
基金 国家自然科学基金资助项目(编号:81402037)
  • 相关文献

参考文献2

二级参考文献12

  • 1C. Iriyama,S. Matsuda,R. Katsumata,M. Hamaguchi.Cloning and sequencing of a novel human gene which encodes a putative hydroxylase[J].Journal of Human Genetics.2001(5)
  • 2Datta P K,Moses H L.STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling[].Molecular and Cellular Probes.2000
  • 3Deng G R,Lu Y Y,Chen S M,et al.Activated c-Ha-ras oncogene with a guanine to thymine transversion at the twelfth codon in a human stomach cancer cell line[].Cancer Research.1987
  • 4Li Y,Lu YY.Isolation of diallyl trisulfide inducible differentially expressed genes in human gastric cancer cells by modified cDNA representational difference analysis[].DNA and Cell Biology.2002
  • 5Zhao J,Zhang X,Xin Y,et al.Up-regulated expression of Ezrinand c-Met proteins are related to the metastasis and prognosis ofgastric carcinomas[].Histology and Histopathology.2011
  • 6Zhang J,Kang B,Tan X, et al.Comparative analysis of the protein profiles from primary gastric tumors and their adjacent regions:MAWBP could be a new protein candidate involved in gastric cancer[].Proteome Res.2007
  • 7Suh Y,Yoon CH,Kim RK,et al.Claudin-1 induces epithelial-mesenchymal transition through activation of the c-Abl-ERK sig-naling pathway in human liver cells[].Oncegene.2012
  • 8CJ Chang,CH Chao,W Xia,JY Yang,Y Xiong,CW Li,WH Yu,SK Rehman,JL Hsu,HH Lee,M Liu,CT Chen,D Yu,MC Hung.p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs[].Nature Cell Biology.2011
  • 9Achyut B R,Yang L.Transforming growth factor-βin the gastrointestinal and hepatic tumor microenviron-ment[].Gastroenterology.2011
  • 10H Jung,HA Seong,H Ha.NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function[].Journal of Biological Chemistry.2007

共引文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部