清热除湿汤对小儿湿热浸淫型湿疹患者的疗效及其对血清T细胞亚群的影响

Clinical Efficacy and Influence of Qingrechushi Mixture in Children Patients with Damp-heat Eczema and Serum T-lymphocyte Subgroup

目的:评价清热除湿汤对小儿湿热浸淫型湿疹患者的疗效及其对清T细胞亚群的影响。方法:选取2015年1月—2017年1月间收治的小儿湿疹(中医辨证为湿热浸淫型)患儿100例临床资料,按照随机数字表法将患儿随机分对照组50例和观察组50例;对照组患儿给予黄柏胶囊治疗;观察组患者给予中药方剂清热除湿汤治疗;评价两组患儿治疗后的总有效率,以及也叫前后的血清T细胞亚群水平和不良反应发生率的变化情况。结果:两组患儿治疗后的EASI和VAS评分值低于治疗前(P<0.05),观察组患儿治疗后的总有效率高于对照组(P<0.05),CD4+、CD4+/CD8+测得值高于对照组(P<0.05)。结论:针对小儿湿热浸淫型湿疹患儿采用中药方剂清热除湿汤治疗小儿湿热浸淫型湿疹患儿的疗效较显著,安全性较高,可有效改善其血清T细胞亚群水平。

Objective： To evaluate the clinical efficacy and influence of qingrechushi mixture in children patients with damp-heat eczema and serum t-lymphocyte subgroup. Methods： 100 cases of children with hot and humid steeped eczema treated in our hospital from January 2015 to January 2017 were selected and randomly divided into a control group and an observation group with 50 cases each. The control group was given Huangbai Capsule, and the observa- tion group was given Qingrechushi Mixture, both two groups were given continuous one month＇s treatment. The effica- cy were evaluated and compared between two groups, and the changes of serum T-lymphocyte subgroup level before and alter treatment and the occurrence of adverse reactions were recorded in detail. Results： The EASI scores and VAS scores after treatment in the observation group were significantly lower than both before treatment in the observation and after treatment in the control group （P〈0.05）. The overall effective rate in the observation group was obviously higher than in the control group （P〈0.05）; The CD4＋ and CD4＋/CD8＋ after treatment in the observation group were significantly higher than before treatment in the observation group and after treatment in the control group （P〈0.05）. Conclusion： Qingrechushi Mixture has a remarkable effect in children patients with damp-heat Eczema, and the serum T cell subgroup level can be improved effectively with high safety.