不同检验方法应用于肺炎支原体感染患儿中的临床诊断价值

Clinical Value of Different Test Methods in Diagnosis of Mycoplasma Pneumoniae Infection

目的探讨检测血清降钙素原及C-反应蛋白对肺炎支原体感染的诊断价值。方法选取我院2016年1—12月500例下呼吸道感染患者为研究对象,其中112例确诊为肺炎支原体肺炎患者纳入此次研究对象,其中66例为急性期,46例为恢复期;另选取医院同期健康体检者36例作为本次研究对照组,分别于患者入院时抽取其空腹下肘静脉血液5 ml,待离心处理后进行检测,采用免疫增强散射比浊法检测其血清降钙素原(PCT)水平,采用Quik Read CRP分析仪分析检测其血清C-反应蛋白(CRP)水平。结果急性期患者PCT及CRP水平分别为(0.29±0.10)ng/ml、(17.1±3.3)mg/L,明显高于恢复期(0.20±0.07)ng/ml、(8.5±3.3)mg/L,差异有显著统计学意义(P<0.05);急性期患者PCT及CRP水平分别为(0.29±0.10)ng/ml、(17.1±3.3)mg/L,明显高于对照组(0.10±0.01)ng/ml、(5.5±1.9)mg/L;恢复期患者PCT及CRP水平明显高于对照组,差异有显著统计学意义(P<0.05)。结论小儿肺炎支原体感染患者血清降钙素原及C-反应蛋白均较正常健康人群高,因此,检测患者血清降钙素原及C-反应蛋白可有助于临床肺炎支原体感染的诊断,从而为临床治疗提供参考。

OBJECTIVE To investigate the diagnostic value of serum procalcitonin and C-reactive protein （CRP） in mycoplasma pneu- moniae infection. METHODS 500 cases of patients with respirattoy tract infection in target hospital in 2016 were selected as the ob- jects. 66 cases were acute and 46 cases were convalescent. On the other hand, 36 healthy subjects were selected as the control group in this study, which were divided into two groups at the time of hospitalization （P〈0.05）. Protein （CRP） levels. The serum levels of pro- calcitonin （PCT） were detected by immunoturbidimetric turbidimetry, and serum C-reaction was detected by Quik Read CRP analyz- er, RESULTS The levels of PCT and CRP in acute stage were （0.29±0.10） ng/ml, （17.1±3.3） mg/L, significantly higher than those in recovery stage （0.20±0.07） ng/ml, （8.5±3.3） （0.29±0.10） ng/ml, （17.1±3.3） mg/L, respectively, which were significantly higher than those in the control group （0.10±0.01） ng/ml, （5.5±1.9） mg/L, respectively. The levels of PCT and CRP in convalescent patients were significantly higher than the control group （P〈0.05）. CONCLUSION Mycoplasma pneumoniae infection in patients with serum procalci- tonin and C-reactive protein were higher than normal healthy people, so the detection of serum procalcitonin and C-reactive protein in clinical diagnosis of mycoplasma pneumoniae infection could be helpful in the diagnosis, so as to provide reference for clinical treatment.