Th22细胞及其细胞因子IL-22与冠心病发病机制的研究进展

Advances in the research on the role of Th22 cells and its cytokine IL-22 on the pathogenesis of coronary heart disease

Th22是近几年新发现的一种辅助型T细胞亚群。Th22细胞及其主要的细胞因子白细胞介素22(IL-22)被证实在各种自身免疫疾病及慢性炎性疾病如类风湿性关节炎、银屑病、慢性异位性皮炎、哮喘、系统性硬化症等患者中均表达异常。然而关于Th22细胞及IL-22在冠心病中的作用及发病机制尚未明确。如能明确Th22及IL-22作用于冠心病的作用机制,可作为防治冠心病的新思路和新靶点。本文就Th22及其主要细胞因子IL-22的最新研究进展及临床应用现状做一全面综述。

Th22 is a newly T helper cell subsets,discovered in recent years.The abnormal expressions of Th22 cells and IL-22 are confirmed in a variety of autoimmune diseases and chronic inflammatory diseases such as rheumatoid arthritis,psoriasis,atopic dermatitis,chronic asthma,systemic sclerosis.However,the current role and pathogenesis of Th22 cells and IL-22 in coronary heart disease is not yet clear.The mechanism of Th22 and IL-22 in coronary heart disease could be used as a new idea and new target for the prevention and treatment of coronary heart disease.To this end,the latest research progress and clinical application of Th22 and its main cytokine IL-22 are summarized as follows.