Nd:YAG激光、CO_2激光局部治疗轻型复发性阿弗他溃疡短期疗效比较研究

Clinical Short-term Effects of Nd:YAG Laser and CO_2 Laser on Minor Aphthous Ulcer

目的:比较Nd:YAG激光和CO_2激光治疗轻型复发性阿弗他溃疡短期临床疗效。方法:选取68例临床上确诊为轻型复发性阿弗他溃疡的患者,随机分为2组,其中Nd:YAG激光治疗组和CO_2激光治疗组各34例。治疗周期3~5d。应用视觉模拟评分法(VAS)及DP分级法评估并比较两组短期疗效。结果 :在激光照射后的第1天、第2天和第3天分别记录两组疼痛指数减少值,其中Nd:YAG激光减少值为:(3.27±0.24)、(4.23±0.26)和(5.60±0.27);CO_2激光组为(2.56±0.27)、(3.40±0.30)和(4.20±0.28),Nd:YAG激光组疼痛指数减少更明显(P<0.05);激光照射治疗后Nd:YAG激光组及CO_2激光组的平均溃疡期分别为(4.07±0.82)d和(5.12±0.26)d,差异具有统计学意义(P<0.05),Nd:YAG激光组及CO_2激光组总有效率分别为100.0%和90.0%,差异具有统计学意义(P<0.05);同时治疗过程中Nd:YAG激光组患者无明显不适反应,而CO_2激光组有6例对疼痛感到紧张,有7例对气味较敏感。结论:Nd:YAG激光治疗MiRAU的疗效优于CO_2激光,且舒适度较好。

Objective： To compare the clinical short-term effects of Nd：YAG laser and CO2 laser in the treatment of minor aphthous ulcer （MiRAU）. Methods： Sixty-eight cases of clinically diagnosed minor aphthous ulcer （MiRAU） patients were randomly divided into 2 groups, namely, the Nd：YAG laser treatment group （Nd：YAG laser group） and CO2 laser treatment group （CO2 laser group） with 34 cases in each group.The treatment period was 3-5 days. By the method of VAS and DP classification, the short-term curative effect of two groups was evaluated and compared. Results： In the first three days after laser treatment, the pain reduction index value of two groups was recorded, respectively. Index value of the Nd： YAG laser was： （3.27±0.24）, （4.23±0.26） and （5.60±0.27）, which was significantly higher than that of the CO2 laser group with the index value of （2.56±0.27）, （3.40±0.30） and （4.20±0.28） （P〈0.05）. After the laser treatment,Ulcer healing time was（4.07±0.82）days in Nd：YAG laser group, which was significantly shortened than the（5.12±0.26）days in CO2 laser group （P〈0.05）. The total effective rate was 100.0% in Nd：YAG laser group and 90.0% in CO2 laser group. Nd： YAG laser group of patients showed no obvious reaction. And CO2 laser group has 6 cases of nervous pain, and 7 cases sensitive to smell. Conclusion： Significant effects on the treatment of MiRAU was observed between Nd：YAG laser and CO2 laser group. By comparison, Nd：YAG laser has more advantages in shortening the healing time and relieving pain.