miRNAs在牙周领域中的研究进展

Research Progress of MicroRNAs in Field of Periodontics

微小分子RNA(microRNAs,miRNAs)是一类内源性非编码小分子RNA,miRNAs在基因表达调控方面具有广泛和普遍的作用,参与了细胞增殖、细胞分化、生物体发生发育等生物学过程.目前对于miRNAs的研究主要集中在肿瘤方面,对于口腔牙周领域的研究甚少,本文根据miRNAs与牙周组织研究的最新进展,就其在牙周炎症性疾病以及成骨、破骨分化中的异常表达及可能机制方面作一论述。

MicroRNAs （miRNAs） are endogenously expressed small noncoding RNAs that regulate gene expres- sion. It plays a critical role in cell proliferation, cell differentiation, and organism development. Current researches on miRNAs mainly focus on its antitumor effect while its role in periodontics lacks attention. This review is focusing on the differential expression of miRNAs in periodontitis, osteoblast, and osteoclast differentiation, and discussing their possible regulation mechanism on the basis of the latest progress on researches of miRNAs in periodontitis.