腹腔镜手术对胆囊结石合并急性胆囊炎患者机体应激及免疫功能的影响

Effects of Laparoscopic Surgery on Stress and Immune Function in Patients with Gallstones Complicated with Acute Cholecystitis

目的:探讨腹腔镜手术对胆囊结石合并急性胆囊炎患者机体应激及免疫功能的影响。方法:收集2014年5月至2017年5月入院的60例胆囊结石合并急性胆囊炎患者随机分为两组,腹腔镜组患者给予腹腔镜手术,传统组患者则给予传统手术,比较两组患者相关临床指标、并发症、应激水平、免疫功能与生活质量。结果:腹腔镜组患者切口瘢痕长度、住院时间与总并发症发生率均显著性低于传统组;术后7d IL-6、CRP、皮质醇、ACTH与血糖水平组间比较均显著性低于传统组;CD3、CD4与CD4/CD8水平组间比较均显著性高于传统组;术后3个月各维度生活质量评分与总分组间比较均显著性高于传统组,差异有统计学意义(P<0.01)。结论:腹腔镜手术对胆囊结石合并急性胆囊炎患者机体应激及免疫功能的影响显著,具有借鉴意义。

Objective： To investigate the effects of laparoscopic surgery on the stress and immune function of patients with cholecystolithiasis complicated with acute cholecystitis.Methods： 60 patients with cholecystolithiasis combined with acute cholecystitis from May 2014 to May 2017 were randomly divided into two groups.Laparoscopic group patients underwent laparoscopic surgery.The patients in the traditional group were given traditional surgery.The related clinical indicators,complications,stress levels,immune function and quality of life were compared.Results： The incision scar length,length of hospital stay and total complication rate in laparoscopic group were significantly lower than those in the traditional group.The levels of IL-6,CRP,cortisol,ACTH and blood glucose were significantly lower than those of the traditional group （P〈0.05）.There was significant difference between the two groups （P〈0.05）.The difference of CD3,CD4 and CD4/CD8 levels between the two groups was significantly higher than that of the conventional group （P〈0.01）.Conclusion： Laparoscopic surgery has a significant effect on the body＇s stress and immune function in patients with gallstone and acute cholecystitis.