病毒性脑炎患儿体内蛋白C水平的测定与临床研究

Determination of Protein C in Serum and Cerebrospinal Fluidin Children with Viral Encephalitis and Clinical Research

目的:探讨病毒性脑炎患儿体内蛋白C水平的变化及其临床意义。方法:选择2013年10月至2015年12月我院收治的102例病毒性脑炎患儿为观察组,另外同期随机选择我院100例因头痛症状就诊最终诊断为上呼吸道感染儿童为对照组。于入院24h内(急性期)和临床治疗1周后(恢复期)采集患儿静脉血与脑脊液标本用于检测蛋白C水平;采集并检测对照组健康儿童静脉血与脑脊液样本中蛋白C水平。结果:观察组患儿急性期血清与脑脊液中蛋白C水平均较恢复期及对照组健康儿童低,差异有统计学意义(P<0.05);观察组中急性期轻症患儿血清和脑脊液中蛋白C水平高于重症患儿,差异有统计学意义(t=2.542、2.115,P<0.05)。结论:蛋白C水平可用于病毒性脑炎的早期诊断和感染严重程度的判断,对诊断病情和指导治疗有重要的临床价值。

Objective： To study the changes of protein C levelsin serum and cerebrospinal fluid （CSF） of children with viral encephalitis and its clinical significance.Method： From October 2013 to December 2015,102 cases of children with viral encephalitis as the observation group,the other in the same period randomly selected 100 cases of children with upper respiratory tract infection with headache as control group.In hospital within 24 h （acute phase） and the clinical therapy （recovery） after 1 weeks to collect children venous blood samples and cerebrospinal fluid samples for detection of protein C levels; collecting and the detecting protein C levels of healthy children in the venous blood samples and samples of cerebrospinal fluid.Results： Observation group with acute phase protein C levels in serum and cerebrospinal fluid were relatively lower than recovery children and healthy children,the differences were statistically significant （P〈0.05）.Observation group children with acute mild protein C levels in serum and cerebrospinal fluid were higher than children with severe,differences were statistically significant （t = 2.542,2.115,P〈0.05）.Conclusion： Protein C levels can be used for the early diagnosis of viral encephalitis and judge the severity of infection,having important clinical value for diagnosis and treatmentof children with viral encephalitis.