卵巢子宫内膜异位囊肿恶变危险因素回顾性分析

Retrospective analysis of risk factors of malignant transformation of ovarian endometriosis cysts

目的有卵巢子宫内膜异位囊肿的女性发生卵巢透明细胞癌和子宫内膜样腺癌的几率远大于没有的女性。本研究拟探讨卵巢子宫内膜异位囊肿恶变的相关危险因素,为临床的预防提供依据。方法回顾性分析2010-06-30-2015-12-31江苏省苏北人民医院收治的17例卵巢子宫内膜异位囊肿恶变患者(病例组)及51例良性卵巢子宫内膜异位囊肿患者(对照组)的临床资料,采用χ~2检验和Logistic回归分析探讨卵巢子宫内膜异位囊肿恶变的危险因素。结果单因素分析显示,年龄(P<0.001)、囊肿直径(P=0.03)、绝经与否(P=0.006)、囊肿有乳头(P<0.001)等因素和卵巢子宫内膜异位囊肿恶变相关。多因素Logistic回归分析显示,年龄≥49岁(OR=1.92,P<0.05)、绝经(OR=3.09,P<0.001)、囊肿直径≥11cm(OR=2.68,P<0.05)、囊壁有乳头(OR=3.63,P<0.05)为卵巢子宫内膜异位囊肿恶变的危险因素。结论年龄≥49岁、已绝经、囊壁有乳头、囊肿直径≥11cm是卵巢子宫内膜异位囊肿恶变的独立危险因素,该类患者囊肿恶变风险增大,应予以积极的干预治疗。

OBJECTIVE The aim of this study was to determine risk factors for the presence of malignant transfor- mation in ovarian endometriotic cysts and provide a reference for the prevention of malignant transformation in ovarian endometriotic cysts. METHODS Seventeen patients with ovarian carcinoma arising in the background of endometriosis and fifty-one patients with benign endometrioma who underwent surgery in Northern Jiangsu Peoples＇ s Hospital between June. 30,2010 and Dec. 31,2015 were selected as the study subjects, and the clinical features were retrospectively reviewed to find the risk factors of malignant transformation in ovarian endometriotic cysts by 2 test and Logistic regression analysis. RESULTS Univariate analysis showed that age （P〈0. 001） ,tumor size （P=0.03） ,menopause （P=0. 006）, papilla （P〈0. 001） were relevent to malignant transformation of ovarian endometriosis cysts. Logistic regression analysis revealed that the factors such as age of 49 years or greater （OR= 1.92, P〈0.05）, menopause（OR= 3.09, P〈0. 001）, tumor size ≥ 11 cm（OR= 2.68, P〈0.05）, papilla （OR = 3.63, P〈 0.05） were risk factors for malignant transformation of ovarian endometriosis cysts. CONCLUSION The patients with age of 49 years or greater,menopause and tumor size ≥11 cm are independent risk factors of malignant transformation of ovarian endometriosis cysts.